Ceftaroline Fosamil

Ceftaroline Fosamil (CAS No.: 400827-46-5) is a semisynthetic cephalosporin derived from antibacterial beta lactam scaffold optimization and is primarily classified as a research grade anti infective tool compound for microbiology, host pathogen interaction studies, and preclinical drug discovery workflows focused on resistant Gram positive organisms, where it functions as a phosphono prodrug precursor of the active ceftaroline species and exerts mechanism based activity through covalent acylation of bacterial penicillin binding proteins including altered resistance associated PBPs in methicillin resistant Staphylococcus aureus, thereby disrupting late stage peptidoglycan crosslinking and cell wall biosynthesis; across published class consistent antibacterial profiling paradigms, potency is typically discussed by minimum inhibitory concentration behavior in the sub micromolar to low micromolar equivalent exposure context depending on strain background and susceptibility phenotype, while molecular and systems level investigations commonly use this agent in susceptibility panels, time kill and resistance selection assays, biofilm related bacterial burden experiments, and translational infection models to benchmark beta lactam performance against comparator agents, with concentrations or doses used in experiments typically depending on specific experimental designs, pathogen inoculum, pharmacokinetic assumptions, and research objectives.