Cefoselis
Cefoselis is a widely used antibiotic of β-lactam [1].
Cefoselis has a large antibacterial spectrum against gram positive bacterium. It is a 4th generation of cephalosporin. Cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. Through testing the dialysate and blood samples by HPLC, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. In renal failure rats, the elimination half-lives of cefoselis are prolonged. It may be one factor of the seizures caused by cefoselis. In addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of GABA, suggesting that cefoselis induces seizures through blocking the GABA receptors [1].
References:
[1] Ohtaki K, Matsubara K, Fujimaru S, Shimizu K, Awaya T, Suno M, Chiba K, Hayase N, Shiono H. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm. 2004 Dec;111(12):1523-35.
| Storage | Store at -20°C |
| M.Wt | 522.56 |
| Cas No. | 122841-10-5 |
| Formula | C19H22N8O6S2 |
| Solubility | Soluble in DMSO |
| Chemical Name | (6R,7R)-3-[[3-amino-2-(2-hydroxyethyl)pyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=C(N4CCO)N)C(=O)[O-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment [1]: | |
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Animal models |
Male Wistar rats |
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Dosage form |
10,50 and 400 mg/kg(i.v.) |
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Application |
Cefoselis appeared in the extracellular fluid of the brain in a dose-dependent manner, which was proportional to the concentration in the blood. The elimination constant of brain extracellular fluid (apparent) was slightly lower than that of blood. In rats with renal insufficiency, the elimination half-lives of cefoselis from both blood and brain were extensively prolonged. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Ohtaki K, Matsubara K, Fujimaru S, Shimizu K, Awaya T, Suno M, Chiba K, Hayase N, Shiono H. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm (Vienna). 2004 Dec;111(12):1523-35. Epub 2004 Jul 7. PubMed PMID:15565489. |
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| Description | Cefoselis is a widely used antibiotic of β-lactam. | |||||
| Targets | β-lactam | |||||
| IC50 | ||||||
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
