Cediranib Maleate

Cediranib Maleate (CAS No.: 857036-77-2) is a synthetic small-molecule receptor tyrosine kinase inhibitor classified as a selective inhibitor targeting the vascular endothelial growth factor receptor family. It is commonly supplied as the maleate salt to facilitate laboratory handling and formulation, and has broad application value in biomedical research and early-stage drug discovery involving angiogenesis, regulation of biological barrier permeability, endothelial cell biology, and the tumor microenvironment; mechanistically, it preferentially targets VEGFR2 while also inhibiting VEGFR1 and VEGFR3, and shows inhibitory activity against PDGFRα, PDGFRβ, and c?Kit, thereby reducing receptor phosphorylation and blocking key signaling nodes such as MAPK and PI3K?AKT, affecting phenotypes related to endothelial cell proliferation, migration, survival, and vascular permeability; in in vitro biochemical and cellular system evaluations, it exhibits sub-nanomolar to low-nanomolar potency against the VEGFR family, while its activity against broader kinase targets is typically in the low to mid-nanomolar range, making it suitable as a reference tool compound for pathway validation, target occupancy and kinetic studies, high-content imaging, and multi-kinase panel screening; studies have reported that in ovarian cancer models it can upregulate MHC class I molecule expression at the transcriptional level, providing experimental evidence for exploring the intersection between angiogenic signaling and tumor immunogenicity; typical applications include perturbing VEGF-driven signaling in endothelial and tumor cell models, evaluating vascular remodeling and perfusion-related parameters in animal models, and optimizing experimental designs related to anti-angiogenesis. The concentrations or doses used in experiments generally depend on the specific protocol and research objectives; this product is for laboratory research use only and is not intended for diagnostic, clinical, or any other human-related applications.