CB-5339

CB-5339 (CAS No.: 1863952-15-1) is a synthetic small molecule research compound broadly categorized as a p97 Valosin Containing Protein inhibitor within the proteostasis and ubiquitin dependent protein quality control field, and it is used as a mechanistic probe in biomedical research and early stage drug discovery workflows focused on stress adaptation in malignant cell systems; based on available reference information and publicly described characterization of this scaffold class, CB-5339 demonstrates high potency against p97 with reported activity in the nanomolar range, including low double digit to single digit nanomolar inhibitory values, consistent with strong pathway engagement in studies of endoplasmic reticulum associated degradation, unfolded protein response signaling, and downstream apoptotic or growth suppressive phenotypes under experimentally controlled conditions; in vitro applications commonly include leukemia and other oncology relevant cell models to assess target modulation, proteotoxic stress biomarkers, cell viability, and combination response profiling, while in vivo use is generally framed in preclinical pharmacology paradigms to examine exposure response relationships and target biology rather than any human use context, and as with other agents in this category, the concentrations or doses used in experiments typically depend on specific experimental designs and research objectives, assay format, model sensitivity, and endpoint selection.