Casin
Catalog No.
B6103
GTPase Cdc42 inhibitor
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Casin (CAS 425399-05-9) is a selective inhibitor targeting Cdc42, a member of the Rho GTPase family involved in regulating actin and microtubule organization, cellular polarity, and cell adhesion. Casin inhibits the active, GTP-bound state of Cdc42 at an IC50 of approximately 2 μM. In vitro, Casin treatment reduces elevated levels of active Cdc42 observed in aged hematopoietic stem cells (HSCs) toward youthful levels, restoring cellular polarization phenotypes. In animal studies, Casin administration reversed age-associated polarity defects in aged HSCs. Casin is under investigation in preclinical aging and stem cell research.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 306.4 |
| Cas No. | 425399-05-9 |
| Formula | C20H22N2O |
| Solubility | ≥30.6 mg/mL in DMSO; insoluble in H2O; ≥19.5 mg/mL in EtOH |
| Chemical Name | 2-((6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethanol |
| SDF | Download SDF |
| Canonical SMILES | OCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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