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Casin

Catalog No.
B6103
GTPase Cdc42 inhibitor
Grouped product items
SizePriceStock Qty
5mg
$81.00
In stock
10mg
$137.00
In stock
50mg
$560.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

Casin (CAS 425399-05-9) is a selective inhibitor targeting Cdc42, a member of the Rho GTPase family involved in regulating actin and microtubule organization, cellular polarity, and cell adhesion. Casin inhibits the active, GTP-bound state of Cdc42 at an IC50 of approximately 2 μM. In vitro, Casin treatment reduces elevated levels of active Cdc42 observed in aged hematopoietic stem cells (HSCs) toward youthful levels, restoring cellular polarization phenotypes. In animal studies, Casin administration reversed age-associated polarity defects in aged HSCs. Casin is under investigation in preclinical aging and stem cell research.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt306.4
Cas No.425399-05-9
FormulaC20H22N2O
Solubility≥30.6 mg/mL in DMSO; insoluble in H2O; ≥19.5 mg/mL in EtOH
Chemical Name2-((6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethanol
SDFDownload SDF
Canonical SMILESOCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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