C14:0 CE

C14:0 CE (CAS No.: 1989-52-2) is a naturally occurring cholesteryl ester (cholesterol myristate) found in biological systems and traditional medicinal sources, widely utilized as a biochemical tool in membrane biology and ion channel research. As a lipid-derived steroidal molecule, it integrates into lipid bilayers and modulates membrane physicochemical properties, thereby influencing the activity of multiple ion channels, including nicotinic acetylcholine receptors, GABAA receptors, and inward-rectifier potassium channels. Through these interactions, it serves as a functional probe for studying ion channel–mediated signal transduction, synaptic transmission, and cellular excitability. In addition to its mechanistic relevance, elevated levels of cholesteryl myristate have been associated with metabolic and cardiovascular pathologies, including non-alcoholic fatty liver disease and atherosclerotic plaque instability, supporting its use as a biomarker-related analyte in disease modeling. In vitro studies suggest that its modulatory effects on membrane proteins typically occur within the nanomolar to micromolar range, depending on the experimental system and lipid environment. Furthermore, its physicochemical properties have enabled its incorporation into lipid nanoparticle formulations as a carrier component for poorly water-soluble compounds, highlighting its utility in drug delivery research. The concentrations or doses used in experiments typically depend on specific experimental designs and research objectives, encompassing applications in cell-based assays, lipidomics studies, and preclinical models of metabolic and cardiovascular disorders.