Bitopertin
Catalog No.
A3242
Glycine reuptake inhibitor(GlyT1)
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Bitopertin (CAS 845614-11-1), also known as RG1678, is a selective inhibitor of glycine transporter-1 (GlyT1), exhibiting an EC50 of 30 nM in vitro. GlyT1 inhibition increases synaptic glycine, a co-agonist at N-methyl-D-aspartate (NMDA) receptor glycine-binding sites, thereby enhancing NMDA receptor-mediated glutamatergic neurotransmission. This mechanism addresses glutamatergic dysfunction implicated in schizophrenia. Clinical studies indicate that adjunctive bitopertin treatment improves negative symptoms in schizophrenia patients, highlighting its therapeutic potential as a GlyT1-targeted research tool and drug candidate.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 543.46 |
| Cas No. | 845614-11-1 |
| Formula | C21H20F7N3O4S |
| Synonyms | RG1678;RO4917838;RG-1678;RG 1678;RO-4917838;RO 4917838 |
| Solubility | insoluble in H2O; ≥17.94 mg/mL in EtOH; ≥88.9 mg/mL in DMSO with ultrasonic |
| Chemical Name | [4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[5-methylsulfonyl-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methanone |
| SDF | Download SDF |
| Canonical SMILES | CC(C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2CCN(CC2)C3=C(C=C(C=N3)C(F)(F)F)F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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