Begacestat
Catalog No.
A4406
γ-secretase inhibitor
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γ-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.
| Physical Appearance | White solid |
| Storage | Store at 4°C |
| M.Wt | 391.74 |
| Cas No. | 769169-27-9 |
| Formula | C9H8ClF6NO3S2 |
| Synonyms | GSI-953 |
| Solubility | <39.17mg/ml in DMSO; <39.17mg/ml in ethanol |
| Chemical Name | 5-chloro-N-[(2S)-4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl]thiophene-2-sulfonamide |
| SDF | Download SDF |
| Canonical SMILES | C1=C(SC(=C1)Cl)S(=O)(=O)NC(CO)C(C(F)(F)F)C(F)(F)F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
