AZD3514
AZD3514 (CAS: 1240299-33-5) is a small-molecule inhibitor targeting the androgen receptor (AR). It is designed to downregulate AR expression, thereby suppressing AR-mediated cellular processes.AZD3514 exerts its biological activity primarily through receptor downregulation. In cell-based studies, AZD3514 demonstrates inhibitory activity, with an IC50 value of 5.75 μM in LNCaP human prostate cancer cells. Based on these pharmacological properties, AZD3514 holds research potential in studies of androgen receptor signaling and prostate cancer.
References:
[1]. Bradbury RH, Acton DG, Broadbent NL, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett, 2013, 23(7): 1945-1948.
[2]. Loddick SA, Ross SJ, Thomason AG, et al. AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther, 2013, 12(9): 1715-1727.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 519.56 |
| Cas No. | 1240299-33-5 |
| Formula | C25H32F3N7O2 |
| Solubility | ≥24.45 mg/mL in DMSO; insoluble in H2O; ≥46.4 mg/mL in EtOH |
| Chemical Name | 1-[4-[2-[4-[1-[3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-1-yl]ethanone |
| SDF | Download SDF |
| Canonical SMILES | CC(=O)N1CCN(CC1)CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5C(F)(F)F)CC4 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | AZD3514 is a small-molecule downregulator of androgen receptor with Ki value of 2.2 μM. | |||||
| Targets | androgen receptor | |||||
| IC50 | 2.2 μM (Ki) | |||||
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
