Azasetron HCl
Catalog No.
B2233
5-HT3 receptor antagonist
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Azasetron HCl (CAS No.: 123040-16-4) is a selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, mainly used for the prevention and treatment of nausea and vomiting induced by cancer chemotherapy. It has high affinity for the 5-HT3 receptor; in vitro studies show an IC50 of approximately 0.33 nM, indicating that it can effectively inhibit 5-HT3 receptor activity at the nanomolar level. In cellular and animal models, Azasetron HCl suppresses the emetic reflex induced by chemotherapeutic agents by blocking 5-HT3 receptors. The doses or concentrations used in experiments typically depend on the experimental design and research objectives.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 386.27 |
| Cas No. | 123040-16-4 |
| Formula | C17H20ClN3O3·HCl |
| Solubility | ≥6.33 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥54.1 mg/mL in H2O |
| Chemical Name | N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CN1c(cc(cc2C(NC3C(CC4)CCN4C3)=O)Cl)c2OCC1=O.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
