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Asterric Acid

Catalog No.
C4549
ETA receptor inhibitor
Grouped product items
SizePriceStock Qty
1mg
$323.00
Ship with 5-10 days
5mg
$1,212.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

IC50: 10 μM for ET-1 binding to the ETA receptor ofA10 cells

Asterric Acid is an ETA receptor inhibitor.

Endothelin (ET), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. Analyses of a human genomic library reveals three forms of ET (ET-1, ET-2 and ET-3) with more than 70% homology with one another. In various organs, high affinity and specific receptors for ET have been found, which have been classfied as receptors ETA and ETB. ET-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the ETA receptor.

In vitro: Previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, Aspergillus sp. Asterric acid had also been reported as a metabolite of a fungus. It was found that asterric acid had the property of inhibiting ET-1 binding to the ETA receptor of A10 cells, but it showed no inhibitory activity against ANP and A II binding at 10 mM, which indicated that asterric acid displayed as a specific inhibitor of ET-1 binding [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Ohashi, H. ,Akiyama, H.,Nishikori, K., et al. Asterric acid, a new endothelin binding inhibitor. Journal of Antibiotics 45, 1684-1685 (1992).

Chemical Properties

Physical AppearanceA white solid
StorageStore at -20°C
M.Wt348.3
Cas No.577-64-0
FormulaC17H16O8
SynonymsDimethylosoic Acid,RES-1214-1,TAN 1415A
SolubilitySoluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide
Chemical Name2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-benzoic acid, 1-methyl ester
SDFDownload SDF
Canonical SMILESCC1=CC(O)=C(C(O)=O)C(OC2=C(OC)C=C(O)C=C2C(OC)=O)=C1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Asterric Acid