Arginase inhibitor 1

Catalog No.

B1009

Human arginases I and II inhibitor

Grouped product items
Size	Price	Stock
2mg	$265.00	Ship with 10-15 days
5mg	$397.00	Ship with 10-15 days
10mg	$695.00	Ship with 10-15 days
50mg	$2,646.00	Ship with 10-15 days

For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Background

Arginase inhibitor 1 is a novel and potent small molecule inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.

Storage	Store at -20°C
M.Wt	286.18
Cas No.	1345808-25-4
Formula	C₁₃H₂₇BN₂O₄
Solubility	Soluble in DMSO
Chemical Name	(R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid
SDF	Download SDF
Canonical SMILES	N[C@](CCN1CCCCC1)(C(O)=O)CCCCB(O)O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Cell experiment [1]:
Cell lines	CHO cells over-expressing human arginase I
Preparation method	This compound is soluble in DMSO. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	0.1, 0.3, 1, 3, 10, 30, 100, and 300 μM; 24 h
Applications	In CHO cells over-expressing human arginase I, Arginase inhibitor 1 inhibited human arginase I with IC50 value of 8 μM.
Animal experiment [1]:
Animal models	MI/RI rat model
Dosage form	100 mg/kg, i.v.; administered as a bolus 15 min before occlusion of the coronary artery
Application	In MI/RI rat model, Arginase inhibitor 1 (100 mg/kg, i.v.) reduced infarct size to 35.2% of area at risk (AAR), similar to the intermittent preconditioning (IPC) group.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1] Wang L, Yu Y, Chow DC et al. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10;28(2):240-52.

Purity = 98.00%