Anti-Topoisomerase I Rabbit Monoclonal Antibody
Catalog No.
MA5468
Anti-Topoisomerase I Rabbit Monoclonal Antibody
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Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.
7150
TOP1; DNA topoisomerase 1; DNA topoisomerase I
Rabbit
Human, Mouse, Rat
Unconjugated
Calculated MW: 91 kDa; Observed MW: 91 kDa
Unmodified
IgG
Monoclonal Antibody
AP-19G11F7
Liquid
See label
Carrier Not Free
A synthetic peptide of human Topoisomerase I
Affinity Purified
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA.
WB, IHC-F, IHC-P, ICC/IF
Blue ice
-20°C
12 months
Please avoid freeze-thaw cycles.