Amphotericin Methyl Ester-d3

Amphotericin Methyl Ester-d3 is a stable isotope-labeled compound of Amphotericin B Methyl Ester and belongs to polyene antifungal and antiviral agents. Amphotericin B exerts antifungal activity by binding to ergosterol in the fungal cell membrane and forming transmembrane channels, leading to leakage of cellular contents. In in vitro studies, Amphotericin B Methyl Ester showed nanomolar to micromolar antiviral activity in HIV-1-infected TZM-bl cells, inhibiting virion production, viral entry, and infectivity. (glpbio.cn) In cell and animal models, Amphotericin B Methyl Ester is mainly used to study its antifungal and antiviral activities, and the dose or concentration used in experiments usually depends on the experimental design and research purpose.