ABC294640
Catalog No.
B1182
Sphingosine kinase 2 inhibitor,selective and competitive
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ABC294640 (CAS 915385-81-8) is a selective, competitive inhibitor of sphingosine kinase-2 (SK2), an enzyme involved in sphingosine-1-phosphate (S1P) synthesis. It competes with sphingosine at the SK2 binding site, exhibiting an IC50 of approximately 60 μM in recombinant human SK2 assays and a Ki of 9.8 μM. ABC294640 effectively reduces S1P levels in MDA-MB-231 cells (IC50 26 μM), leading to inhibition of proliferation and migration across multiple cancer cell lines, including 1025LU, A-498, Caco-2, and HT-29. Additionally, it demonstrates antitumor activity in xenograft breast cancer models, indicating potential for oncology and endocrine research applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 380.91 |
| Cas No. | 915385-81-8 |
| Formula | C23H25ClN2O |
| Solubility | ≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH |
| Chemical Name | (7S)-3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
