ω-Agatoxin IVA
Catalog No.
B7192
P-type calcium channels blocker
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ω-Agatoxin IVA (CAS 145017-83-0) is a peptide neurotoxin isolated originally from spider venom. It selectively inhibits voltage-gated P/Q-type calcium channels (Cav2.1), blocking calcium ion influx across neuronal membranes. By binding with high affinity to these calcium channels, ω-Agatoxin IVA suppresses neurotransmitter release at presynaptic terminals. Researchers routinely utilize ω-Agatoxin IVA to investigate neurotransmission, presynaptic calcium signaling, and the physiological or pathological roles of P/Q-type calcium channels in neuronal function.
| Physical Appearance | White lyophilised solid |
| Storage | Desiccate at -20°C |
| M.Wt | 5202.25 |
| Cas No. | 145017-83-0 |
| Formula | C217H360N68O60S10 |
| Solubility | Soluble in H2O |
| SDF | Download SDF |
| Canonical SMILES | CCC(C1/C(O)=N/C(/C(O)=N/C(/C(O)=N\C(/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(C(O)=NC(C(O)=NC(C(O)=NCC(O)=NCC(O)=NC(C2=O)C(O)C)CC3=CNC4=CC=CC=C34)CCCCN)CSSCC5/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N\C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/6)CC(O)=N)C(O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |