1-methyl Adenosine

1-methyl Adenosine (CAS No.: 15763-06-1) is a naturally occurring modified nucleoside derived from transfer RNA processing by methyltransferases and represents a prominent RNA epitranscriptomic mark involved in the regulation of gene expression and cellular homeostasis. As an RNA modification, it plays a significant role in diverse pathophysiological processes, particularly in cancer biology, where elevated levels in serum and urine have been correlated with tumor development and progression, supporting its utility as a potential biomarker. Mechanistically, 1-methyladenosine has been associated with the modulation of metabolic and oncogenic pathways, including the upregulation of peroxisome proliferator-activated receptor delta (PPARδ), which influences cholesterol metabolism, and the activation of the Hedgehog signaling pathway, thereby contributing to liver tumorigenesis. In addition to oncology, increased levels have also been observed in inflammatory conditions such as active rheumatoid arthritis, indicating broader relevance in disease monitoring. In vitro and in vivo studies typically explore its biological effects within concentration ranges spanning nanomolar to micromolar levels, depending on the experimental system and objectives. Consequently, 1-methyladenosine is widely employed in studies of RNA modification, cancer metabolism, and signaling pathway regulation, as well as in biomarker discovery and therapeutic target validation in cell-based assays and animal models.