1,1,1,1-Kestohexaose
1,1,1,1-Kestohexose is a fructooligosaccharide identified in M. officinalis that exhibits both neuroprotective and antidepressant-like activities.[1,2] It has been shown to prevent corticosterone (Item No. 16063)-induced decreases in cell viability and nerve growth factor (NGF) expression in PC12 cells at concentrations of 0.625 and 1.25 μM.[1] Furthermore, administration of 1,1,1,1-Kestohexose (20 mg/kg) significantly reduces immobility time in the forced swim test in rats, indicating its potential antidepressant effects.[2]
References:
[1] Li YF, Liu YQ, Yang M, Wang HL, Huang WC, Zhao YM, Luo ZP. The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone. Life Sci. 2004 Aug 13;75(13):1531-8. doi: 10.1016/j.lfs.2004.02.029. PMID: 15261759.
[2] Zhang, Z.-Q & Yuan, Lingwen & Zhao, N. & Xu, Y.-K & Yang, M. & Luo, Z.-P. (2001). Effect of inulin-type hexasaccharide on forced swimming tests in mice and rats and DRL 72 s in rats. Chinese Pharmacological Bulletin. 17. 164-167.
| Storage | Desiccate at -20°C away from light |
| M.Wt | 990.86 |
| Cas No. | 62512-19-0 |
| Formula | C36H62O31 |
| Synonyms | GF5; Inulin-type Hexasaccharide |
| Chemical Name | (2R,3R,4S,5S,6R)-2-(((2S,3S,4S,5R)-2-((((2R,3S,4S,5R)-2-((((2R,3S,4S,5R)-2-((((2R,3S,4S,5R)-2-((((2R,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-3,4-dihydro |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1[C@@H](CO)O[C@H](O[C@@]2(CO[C@@]3(CO[C@@]4(CO[C@@]5(CO[C@@]6(CO)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@H](O)[C@H]1O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
