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MEK1/2

A5573 Pimasertib (AS-703026)

Target: MEK

Summary: MEK1/2 inhibitor

≥21.55 mg/mL
A1337 U0126-EtOH
10 Citation

Target: MEK

Summary: MEK1/2 inhibitor

≥21.33 mg/mL
A1792 PD184352 (CI-1040)

Target: MEK

Summary: Selective MEK inhibitor

≥47.9 mg/mL
A1894 SL-327
1 Citation

Target: MEK

Summary: Selective MEK1/2 inhibitor

insoluble in H2O; insoluble in EtOH; ≥16.75 mg/mL
A1663 PD98059
9 Citation

Target: MEK

Summary: MEK inhibitor,selective and reversible

insoluble in EtOH; insoluble in H2O; ≥40.23 mg/mL
A8207 AZD6244 (Selumetinib)
3 Citation

Summary: MEK inhibitor

≥22.88 mg/mL
A3887 Trametinib DMSO solvate
1 Citation

Target: MEK

Summary: Allosteric MEK1/MEK2 kinase inhibitor

insoluble in EtOH; insoluble in H2O; ≥11.2 mg/mL
A3805 SCH772984
7 Citation

Summary: ERK1 and ERK2 inhibitor

insoluble in EtOH; insoluble in H2O; ≥14.7 mg/mL
A3594 MEK inhibitor

Summary: Potent MEK inhibitor, Antitumor agent

Soluble in DMSO
A3323 Cobimetinib (R-enantiomer)

Summary: Selective MEK inhibitor

Soluble in DMSO