Signaling pathways
-
BA2321 MertansineSummary: Mertansine (DM1) is an inhibitor and an antibody-conjugatable medetomidine alkaloid used to overcome the systemic toxicity associated with medetomidine and to enhance tumor-specific delivery. - BA2322 ExatecanSummary: Exatecan (DX-8951) is a DNA topoisomerase I inhibitor.
- BA2323 DM4Summary: DM4 is an anti-microtubule protein agent that inhibits cell division.
- BA2324 SG3199Summary: SG3199 is a cytotoxic DNA minor groove interstrand cross-linked PBD dimer.
- BA2325 PNU-159682Summary: PNU-159682, a metabolite of anthracycline neomycin, is a DNA topoisomerase II inhibitor with excellent cytotoxicity.
- BA2326 TaltobulinSummary: Taltobulin (HTI-286) is a synthetic tripeptide cysteine analog, Taltobulin is a potent anti-microtubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
- BA2327 Seco-DUBASummary: Seco-DUBA is a doxorubicin (DUBA) prodrug containing two hydroxyl groups, each of which can be coupled to an antibody via a linker.
- BA2328 SJG-136Summary: SJG-136 is an effective DNA cross-linking agent.
- BA2329 CC-885-CH2-PEG1-NH-CH3Summary: CC-885-CH2-PEG1-NH-CH3 is a new degradant.
- BA2330 PF-06380101Summary: PF-06380101 (Aur0101), a microtubule inhibitor.