Signaling pathways
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BA2325 PNU-159682Summary: PNU-159682, a metabolite of anthracycline neomycin, is a DNA topoisomerase II inhibitor with excellent cytotoxicity. - BA2326 TaltobulinSummary: Taltobulin (HTI-286) is a synthetic tripeptide cysteine analog, Taltobulin is a potent anti-microtubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
- BA2327 Seco-DUBASummary: Seco-DUBA is a doxorubicin (DUBA) prodrug containing two hydroxyl groups, each of which can be coupled to an antibody via a linker.
- BA2328 SJG-136Summary: SJG-136 is an effective DNA cross-linking agent.
- BA2329 CC-885-CH2-PEG1-NH-CH3Summary: CC-885-CH2-PEG1-NH-CH3 is a new degradant.
- BA2330 PF-06380101Summary: PF-06380101 (Aur0101), a microtubule inhibitor.
- BA2331 MaytansinolSummary: Maytansinol (AnsamitocinP-0) is a derivative of Medenin.
- BA2332 SG2057Summary: SG2057 (DRG16) is a PBD dimer containing a glutaraldehyde bond that selectively binds sequences in the minor groove to form inter- and intra-strand cross-linked adducts of DNA.
- BA2333 T01-1Summary: T01-1 is an anticancer agent (camptothecin derivative).
- BA2334 MMAF-OMeSummary: MMAF-Ome is a tubulin inhibitor, a toxic molecule belonging to the ADC, and is able to inhibit four tumor cells, MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji(5T4).