Cytoskeletal Signaling
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BA2983 BatabulinSummary: Batabulin (T138067) is an antitumor agent that covalently and selectively binds to a subset of beta-microtubule protein isoforms, thereby disrupting microtubule polymerization. - BA2973 IndibulinSummary: Indibulin (ZIO301), an orally effective synthetic inhibitor with good anticancer activity and minimal neurotoxicity.
- BA2948 VerubulinSummary: Verubulin (MPC-6827) is a potent, broad-spectrum blocker.
- BA2942 LCH-7749944Summary: LCH-7749944 (GNF-PF-2356) is a potent inhibitor.
- BA2911 IrigeninSummary: Irigenin is a lead compound that mediates its anti-metastatic effects by specifically and selectively blocking the ExtraDomainA (EDA) domain on the C-C loop and at integrin binding sites.
- BA2854 BTT-3033Summary: BTT-3033 is an orally active conformation-selective (130nM) inhibitor that binds to the α2Idomain.
- BA2331 MaytansinolSummary: Maytansinol (AnsamitocinP-0) is a derivative of Medenin.
- BA2326 TaltobulinSummary: Taltobulin (HTI-286) is a synthetic tripeptide cysteine analog, Taltobulin is a potent anti-microtubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
- BA6475 DLK-IN-1Summary: DLK-IN-1 is a selective inhibitor of double leucine zipper kinase with oral activity.
- BA4302 ViltolarsenSummary: Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino substituted antisense oligonucleotide.