Signaling pathways
-
BA7806 TP0463518Summary: A potent inhibitor of the hypoxia-inducible factor prolyl hydroxylase(s). - BA7808 IzilendustatSummary: Izilendustat is a potent prolyl hydroxylase inhibitor that stabilizes hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2 (HIF-2).
- BA7809 HIF-IN-1Summary: HIF-IN-1 is a hypoxia-inducible factor (HIF-1) inhibitor.
- BA7810 MersalylSummary: Mersalyl (Salirgan) is a potent inducer of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1).
- BA7811 VHL-IN-1Summary: VHL-IN-1 is an inhibitor of the ubiquitin E3 ligase vonHippel-Lindau (VHL) (dissociation constant Kd=37nM) that stabilizes and induces HIF-1α transcriptional activity.
- BA7812 THS-044Summary: Binds and stabilizes the HIF2αPAS-B folding state and regulates HIF2 activity.
- BA7813 HIF1-IN-3Summary: HIF1-IN-3 is a potent inhibitor.
- BA7814 GSK360ASummary: GSK360A is an orally active inhibitor with values of 10, 100 and 126 nM for PHD1, PHD2 and PHD3, respectively.
- BA7815 HIF-PHD-IN-1Summary: HIF-PHD-IN-1 is an orally active inhibitor of the structural domain of the hypoxia-inducible factor prolyl hydroxylase.
- BA7816 ZINC13466751Summary: ZINC13466751 is a potent inhibitor of the interaction.