Signaling pathways
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BA7729 DY268Summary: DY268 is an antagonist of the farnesoid X receptor (=7.5 nM). - BA7730 OmesdafexorSummary: Omesdafexor is an agonist.
- BA7731 NDBSummary: NDB is a selective human antagonist that efficiently regulates the transcription of genes downstream of FXRα.
- BA7732 HEC96719Summary: HEC96719 is a selective as well as orally active tricyclic farnesoid X receptor agonist with values of 1.37 and 1.55 nM by time-resolved fluorescence energy transfer (TR-FRET) and luciferase reporter assays, respectively.
- BA7733 GSK2324Summary: GSK2324 is an agonist.
- BA7734 GKA50Summary: GKA50 is a potent glucokinase activator (=33nM).
- BA7735 MK-0941Summary: MK-0941 is a potent, orally available allosteric activator of glucokinase.
- BA7736 AZD1656Summary: AZD1656 is a potent, selective, orally active glucokinase activator.
- BA7737 AMG-3969Summary: AMG-3969 is a potent disruptor of glucokinase-glucokinase regulatory protein interactions.
- BA7738 CadisegliatinSummary: Cadisegliatin (TTP-399) is a potential liver-selective glucokinase activator with oral activity.