Transferase
Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.
- C4135 OU749Summary: γ-Glutamyl transferase (GGT) inhibitor
- C3463 BCATc Inhibitor 2Summary: cytosolic BCAT (BCATc) inhibitor
- C3203 FTase Inhibitor IISummary: Ftase inhibitor
- B6134 Amodiaquine dihydrochloride dihydrateSummary: histamine N-methyl transferase inhibitor
- B6062 Manumycin ASummary: farnesyltransferase inhibitor
- B5842 FTI 277 HClSummary: FTase inhibitor
- B5729 GPP 78 hydrochlorideSummary: NAMPT inhibitor
- B5521 LY 78335Summary: phenylethanolamine-N-methyltransferase (PNMT) inhibitor
- B7402 Tris DBASummary: N-myristoyltransferase-1 (NMT-1) inhibitor
- B6331 SKF 91488 dihydrochlorideSummary: histamine N-methyltransferase inhibitor