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Fulvestrant (ICI 182,780)
Estrogen receptor antagonist,high affinity

Fulvestrant (ICI 182,780)

Catalog No. A1428
Size Price Stock Qty
10mM (in 1mL DMSO) $55.00 In stock
25mg $50.00 In stock
100mg $100.00 In stock

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Sample solution is provided at 25 µL, 10mM.

Product Citations

1. Li, Han, et al. "Triptolide inhibits human breast cancer MCF-7 cell growth via downregulation of the ERα-mediated signaling pathway." Acta Pharmacologica Sinica (2015). PMID:25864647

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Chemical structure

Fulvestrant

Related Biological Data

Fulvestrant (ICI 182,780)

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Chemical Properties

Cas No. 129453-61-8 SDF Download SDF
Chemical Name (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Canonical SMILES CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
Formula C32H47F5O3S M.Wt 606.77
Solubility >30.4mg/mL in DMSO Storage Store at -20°C
General tips No
Shipping Condition No

Background

Fulvestran is a newer type of estrogen receptor (ER) antagonist with IC50 value of 0.094nM [1].

Fulvestrant treatment caused a significant decrease in MDM2 protein expression in human breast cancer cell lines MCF7 and T47D, and that the reduction of MDM2 correlated with the decrease in ER expression [1].

Fulvestrant enhances the sensitivity of human breast cancer cells to chemotherapeutic drugs. CompuSyn analyses showed that combined use of doxorubicin, paclitaxel or etoposide with fulvestrant resulted in different degrees of synergism in MCF7 and T47D cell lines tested. Besides, Combination of fulvestrant and chemotherapeutic drugs induces altered cell cycle distribution, apoptosis, and senescence [1].

References:
[1] Dolfi SC1, Jäger AV2, Medina DJ1, Haffty BG3, Yang JM4, Hirshfield KM5.Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014 Apr 18. pii: S0304-3835(14)00215-8.