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ArctigeninAnti-inflammatory, antiproliferative

Arctigenin

Catalog No. N2399
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20mg $100.00 Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Arctigenin

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Chemical Properties

Cas No. 7770-78-7 SDF Download SDF
Synonyms (-)-Arctigenin
Chemical Name (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
Canonical SMILES COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
Formula C21H24O6 M.Wt 372.41
Solubility >17.2mg/mL in DMSO Storage Desiccate at -20°C
General tips N/A
Shipping Condition N/A

Background

Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.