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Catalog No.
organic heterocyclic compound
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Tetrazole is the simplest compound belonging to tetrazoles family, a class of synthetic organic heterocyclic compound consists of a 5-member ring of four nitrogen and one carbon atom. Tetrazoles have commonly been believed to have similar properties to carboxylic acids, and therefore make themselves excellent bioisosteres. Moreover, several pharmaceutical agents, for instance, losartan and candesartan (Angiotensin II receptor blockers), are considered as tetrazoles. Tetrazoles are often adopted in medicinal chemistry as a substitute for carboxylic acids because they share very similar proton dissociation properties. [1]

In vitro: The acidity constant of tetrazole was detected and reported as 4.9. Four of the six angiotension II receptor antagonists clinically effective for treating hypertension contained a tetrazole. MTT, dimethyl thiazolyl diphenyl tetrazolium bromide, was regarded as a well-known tetrazole applied to quantify the respiratory activity of live cells. Some tetrazoles could also be used in DNA assays. [2]

In vivo: So far, no in vivo data has been reported.

Clinical trial: So far, no clinical trial has been conducted.

[1]Berner S, Mühlegger K and Seliger H.  Studies on the role of tetrazole in the activation of phosphoramidites. Nucleic Acids Res. 1989 Feb; 17 (3): 853–864
[2]Satchell JF and Smith BJ.  Calculation of aqueous dissociation constants of 1,2,4-triazole and tetrazole: A comparison of solvation modelsy. Phys Chem Chem Phys. 2002; 4: 4314-8.

Chemical Properties

StorageStore at -20°C
Cas No.288-94-8
Solubility≥13.1 mg/mL in DMSO; ≥22.8 mg/mL in EtOH; ≥28 mg/mL in H2O
Chemical Name2H-tetrazole
SDFDownload SDF
Canonical SMILESC1=NNN=N1
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

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