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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production.Ranitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and oth
Cell lines
SVN neurons
Preparation method
The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.
Reacting condition
1 μM
Applications
Ranitidine at 1 μM potently blocked the excitatory responses of SVN neurons to histamine (1 ~ 30 μM). Ranitidine significantly reduced the 23.6%, 35.1% and 48.7% increases in the peak firing rate induced by 1, 3 and 10 μM histamine to 7.1%, 13.7% and 18.3%, respectively. In addition, Ranitidine (1 μM) in combination with Mepyramine (1 μM) almost completely blocked the histamine-induced excitation.
Animal models
Wistar rats
Dosage form
25 mg/mL, 2 drops
In Wistar rats, Ranitidine induced progressive vasoconstriction, with a maximum of 27% decrease in the vascular diameter at 300th s. The administration of histamine after Ranitidine increased the vascular diameter which was relative to the value at 300th s. However, at 600th s, the vascular diameter still could not reach the initial value (at 0th s).
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Zhuang QX, Wu YH, Wu GY, Zhu JN, Wang JJ. Histamine excites rat superior vestibular nuclear neurons via postsynaptic H1 and H2 receptors in vitro. Neurosignals. 2013;21(3-4):174-83.
[2]. Coman OA, Rotar C, Stoleru S, Ghi-Cristescu I, Punescu H, Fulga I. Influencing vascular reactivity in vivo by histaminergic agonists and antagonists. Rom J Morphol Embryol. 2007;48(4):403-6.