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Nepafenac

Catalog No.
A2890
COX-1 and COX-2 inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$55.00
In stock
25mg
$50.00
In stock
100mg
$176.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Nepafenac is a non-steroidal anti-inflammatory drug (NSAID). The IC50 values of nepafenac for (cyclooxygenase-1) COX-1 and COX-2 are 250 nM and 150 nM, respectively [1].

Nepafenac showed to significantly decrease the retinal levels of PGE2 in LPS-induced rats when administrated topically. However, nepafenac has revealed no significant effect on BRB permeability in LPS-induced rat model [1].

Nepafenac significantly reduced proliferation rate of human uveal melanoma cell lines including SP6.5, 92.1, OCM-1, MKT-BR and of human transformed uveal melanocyte cell line UW-1. Compared to rofecoxib, nepafenac might reveal a better systemic safety profile [2].

References:
[1] Bucolo C1, Marrazzo G, Platania CB, Romano GL, Drago F, Salomone S. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation. J Pharm Pharmacol. 2014 Jul;66(7):954-60.
[2] Marshall JC1, Caissie AL, Cruess SR, Cools-Lartigue J, Burnier MN Jr. The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. J Carcinog. 2007 Nov 27;6:17.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt254.28
Cas No.78281-72-8
FormulaC15H14N2O2
Solubilityinsoluble in EtOH; insoluble in H2O; ≥9.95 mg/mL in DMSO
Chemical Name2-(2-amino-3-benzoylphenyl)acetamide
SDFDownload SDF
Canonical SMILESC1=CC=C(C=C1)C(=O)C2=C(C(=CC=C2)CC(=O)N)N
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.

Quality Control

Quality Control & MSDS

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Chemical structure

Nepafenac