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Colistin Methanesulfonate (sodium salt)

Catalog No.
C3046
prodrug for antibiotic colistin (also known as polymyxin E)
Grouped product items
SizePriceStock Qty
1g
$152.00
In stock
5g
$684.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

Colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin E), which is an antibiotic with effect against most Gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. Colistin is produced by certain strains of the bacteria Paenibacillus polymyxa, and belongs to the class of polypeptide antibiotics known as polymyxins.

In Vitro: Studying the time-kill kinetics of Colistin methanesulfonate against a type culture of pseudomonas aeruginosa found that 8.0 or 32 mg/l Colistin methanesulfonate began killing at approximately 90 or 30 min, and the mean AUC0-240 values were 186.3±6.0 and 90.4±4.1, respectively [2]. Besides, by investigation among mucoid and nonmucoid strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis, Colistin methanesulfonate was found to require a concentration of 16 times the MIC to achieve complete killing within 24 h [3].

In Vivo: no data available.

Clinical trial: no data available.

References:
[1] Nation R L, Li J.  Colistin in the 21st century.[J]. Current Opinion in Infectious Diseases, 2009, 22(6): 535-543.
[2] Bergen P J, Li J, Rayner C R, et al.  Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa.[J]. Antimicrobial Agents and Chemotherapy, 2006, 50(6): 1953-1958.
[3] Li J, Turnidge J D, Milne R W, et al.  In Vitro Pharmacodynamic Properties of Colistin and Colistin Methanesulfonate against Pseudomonas aeruginosaIsolates from Patients with Cystic Fibrosis[J]. Antimicrobial Agents and Chemotherapy, 2001, 45(3): 781-785.

Chemical Properties

StorageStore at -20°C
M.Wt1749.8
Cas No.8068-28-8
FormulaC58H105N16O28S5·5Na
SynonymsColimycin M,Polymyxin E sodium methanesulfonate
Solubility≥53.9 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
Chemical Namesodium (Z)-N-((6Z,9Z)-7,10-dihydroxy-8-(1-hydroxyethyl)-5-((Z)-oxido(((1Z,4E,7Z,10Z,13Z,16Z,19Z)-2,5,11,14-tetrahydroxy-3-(1-hydroxyethyl)-12,15-diisobutyl-8,17,20-trioxido-6,9,18-tris(2-((sulfomethyl)amino)ethyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,
SDFDownload SDF
Canonical SMILESCCC(CCCC/C([O-])=N/C(/C(O)=N/C(/C(O)=N/C(/C([O-])=N/C(/C([O-])=N/C(/C([O-])=N/C(/C(O)=N/C(/C(O)=N/C(/C([O-])=N/C(/C(O)=N\1)CCNCS(O)(=O)=O)CCNCS(O)(=O)=O)CC(C)C)CC(C)C)CCNCS(O)(=O)=O)CC/N=C(O)/C1C(O)C)CCNCS(O)(=O)=O)C(O)C)CCNCS(O)(=O)=O)C.[Na+].[Na+].[Na+]
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.

Protocol

Cell experiment [1]:

Cell lines

P. aeruginosa

Preparation method

The solubility of this compound in H2O is ≥ 53.9mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0.5~1mg/l

Applications

Colistin methanesulfonate has a MIC range of 0.5 to 1 mg /l. In addition, by investigating among the mucoid and non-mucoid strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients, it was found that colistin methanesulfonate requires 16 times the MIC concentration to completely kill the bacteria within 24 hours.

References:

[1]. Bozkurt-Guzel C, Gerceker AA. In vitro pharmacodynamic properties of colistin methanesulfonate and amikacin against Pseudomonas aeruginosa. Indian J Med Microbiol. 2012 Jan-Mar;30(1):34-8. PubMed PMID: 22361758.

Quality Control

Quality Control & MSDS

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Chemical structure

Colistin Methanesulfonate (sodium salt)