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Bardoxolone

In stock
Catalog No.
A3220
Once-a-day treatment for CKD
Grouped product items
SizePriceStock Qty
50mg
$164.00
In stock
500mg
$657.00
In stock

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Worldwide Distributors

Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2, an important biological target that controls the production of many of the body's antioxidant and detoxification enzymes. Because oxidative stress and inflammation occur throughout the course of chronic kidney disease (CKD) and are known to contribute to loss of kidney function, agents that activate the Nrf2 pathway in patients with CKD may provide a novel method for preserving or improving kidney function. Bardoxolone methyl is currently being investigated as a potential oral once-a-day treatment for CKD.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt491.66
Cas No.218600-44-3
FormulaC31H41NO4
SynonymsCDDO;RTA 401;RTA401;RTA-401
Solubility≥49.2 mg/mL in DMSO, ≥2.682 mg/mL in EtOH with ultrasonic and warming, <2.31 mg/mL in H2O
Chemical Name(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid
SDFDownload SDF
Canonical SMILESCC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

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