In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Caspofungin is an inhibitor of β-1,3-glucan synthase with IC50 value of 0.6 nmol/L in membrane preparations of C. albicans [1, 2].
β-1,3-glucan synthase plays a critical role in biosynthesis of β-(1,3)-D-glucan, an essential cell wall component of many pathogenic fungi that is absent in the mammalian host. Inhibition of β-1,3-glucan synthase provides a potential therapeutic option for treating serious and life-threatening fungal infections .
Caspofungin exhibited inhibitory effect against 400 bloodstream Candida species with MIC90 value of 0.25 μg/mL. Moreover, all azole-resistant isolates were susceptible to Caspofungin at concentrations of ≤ 0.5 μg/mL. In addition, Caspofungin showed a postantifungal effect against C. albicans, which lasted for 6 ~ 8 h, at concentrations of 0.125 ~ 1 μg/mL .
In 140 patients with mucosal candidiasis, 63% of whom had esophageal involvement and 98% of whom had acquired immunodeficiency syndrome (AIDS), the response rates among the Caspofungin recipients (35, 50, or 70 mg, i.v., q.d., for 7 ~ 14 d) with exclusively oropharyngeal infections was 84% ~ 93%, higher than 67% among those assigned to receive Amphotericin B (0.5 mg/kg, i.v., q.d., for 7 ~ 14 d) .
. Leonard W R Jr, Belyk K M, Conlon D A, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. The Journal of Organic Chemistry, 2007, 72(7): 2335-2343.
. Deresinski S C, Stevens D A. Caspofungin. Clinical Infectious Diseases, 2003, 36(11): 1445-1457.
|Physical Appearance||A solid|
|Storage||Store at -20°C|
|Solubility||≥48.1 mg/mL in DMSO|
|Canonical SMILES||O=C([[email protected]@H]1C[[email protected]@H](O)CN1C([[email protected]@H](NC(C2CC(CCCCCCCCC(C)CC(CC)C)=O)=O)[[email protected]@H](C)O)=O)N[[email protected]@H]([[email protected]](O)[[email protected]@H](O)C3=CC=C(O)C=C3)C(N[[email protected]@H]([[email protected]](O)CCN)C(N4CC[[email protected]](O)[[email protected]]4C(N[[email protected]@H](NCCN)[[email protected]](O)C2)=O)=O)=O|
|Shipping Condition||Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.|
|General tips||For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.|