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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

product-structure
  1. Cat.No. Product Name Information
  2. A8182 3-Deazaneplanocin A (DZNep) hydrochloride SAHH and ENZ2 inhibitor
  3. A1905 3-Deazaneplanocin,DZNep S-adenosylhomocysteine and EZH2 inhibitor
  4. C3552 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor
  5. A4524 4-HQN PARP inhibitor
  6. C4018 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor
  7. B4106 4SC-202 Class I HDAC inhibitor
  8. C3505 5-(N,N-dimethyl)-Amiloride (hydrochloride) NHE1, NHE2, and NHE3 inhibitor
  9. A1907 5-Azacytidine DNA methyltransferase inhibitor.
  10. B4947 A 366 G9a/GLP histone lysine methyltransferase inhibitor
  11. A4160 A-966492 PARP-1/-2 inhibitor, highly potent

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