Search results for: 'research-area tyrosine-kinase tie-2'
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Tie2 kinase inhibitorCatalog No. :A5979Tie-2(Tie2 ) inhibitorTie2 Kinase Inhibitor is a cell-permeable pyridinylimidazole which has been reported to act as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie-2(Tie2 )with a reported ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over Flk-1(VEGFR2), Flt-4 (VEGFR3), and PDGFR-β (PDGFR1&beta);.
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Tienilic AcidCatalog No. :B7928 -
DiscoveryProbe™ Tyrosine Kinase/Adaptors-related Compounds PanelCatalog No. :L1018A wide range of well-characterized bioactive molecules that covers various targets related to tyrosine kinase/adaptors, including ALK, c-MET, VEGFR and Src etc. -
DiscoveryProbe™ Tyrosine Kinase Inhibitor LibraryCatalog No. :L1028A unique collection of 270 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS). -
R406Catalog No. :A8546SYK inhibitor,potent and ATP-competitiveR406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins. It is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development.
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R406 (free base)Catalog No. :A5880Syk inhibitorR406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins. It is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. -
MNSCatalog No. :A8661Inhibitor of Src/Syk tyrosine kinasesSelective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). -
BAY 61-3606 dihydrochlorideCatalog No. :A3228Syk tyrosine kinase inhibitorBAY 61-3606 dihydrochloride -
R788 disodiumCatalog No. :A8332Syk inhibitor,ATP competitive and potentR788 (prodrug of R406;Fostamatinib Disodium Hexahydrate) is part of a new class of rheumatoid arthritis drugs that blocks syk kinase, which can trigger the inflammation that is a hallmark of RA, thereby stopping the progression of the disease. -
PRT062607 HydrochlorideCatalog No. :A3736SYK inhibitor,potent and selectivePRT062607 Hydrochloride is a highly selective and novel SYK inhibitor with IC50 value of 1 nM.