Search results for: 'research-area stem-cell hippo-signaling'
- PRIMA-1Catalog No. :A4483BAX inhibitorSelectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of human tumors with mutant p53.
- Tenovin-1Catalog No. :A4203SIRT2 inhibitor, activates p53Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis.
- JNJ-26854165 (Serdemetan)Catalog No. :A4204P53 activator, blocking Mdm2-p53 interaction
JNJ-26854165, also named as Serdemetan, is originally developed as an activator of p53, is now regarded as a novel oral Human Double Minute-2 (HDM-2) ubiquitin ligase antagonist.