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Tenovin-1

In stock
Catalog No.
A4203
SIRT2 inhibitor, activates p53
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$55.00
In stock
Evaluation Sample
$28.00
In stock
25mg
$90.00
In stock
50mg
$170.00
In stock
100mg
$330.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. Tenovin-1 also exerts inhibition against human sirtuin 1 (SirT1) and sirtuin 2 (SirT2), two important members of the sirtuin family. Due to its insufficient solubility, an improved and water-soluble version of tenovin-1 has been found to decrease the peptide deacetylase activity of human SirT1 and SirT2 with values of 50% inhibition concentration IC50 of 21 μM and 10 μM respectively.

Reference

Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. doi: 10.1016/j.ccr.2008.03.004.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt369.5
Cas No.380315-80-0
FormulaC20H23N3O2S
Solubility≥15 mg/mL in DMSO with gentle warming, <2.51 mg/mL in EtOH, <2.45 mg/mL in H2O
Chemical NameN-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
SDFDownload SDF
Canonical SMILESCC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description Tenovin-1 is inhibitor of MDM2-mediated p53 degradation.
Targets p53          
IC50            

Quality Control

Chemical structure

Tenovin-1

Related Biological Data

Tenovin-1

Related Biological Data

Tenovin-1