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APExBIO

3,3'-Diindolylmethane

In stock
Catalog No.
A3118
Anticancer and antineoplastic agent
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$50.00
In stock
100mg
$50.00
In stock
1g
$160.00
In stock

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3,3'-Diindolylmethane is an anticancer agent [1].

3,3'-Diindolylmethane (DIM) is a dimer of indole-3-carbinol generated in low pH environment. It inhibited cell growth with IC50 values of 17, 24 and 30 μM in MCF-7, T47D and Saos2 cell lines, respectively. DIM induced apoptosis in these cells without affecting the p53 pathway. In human nasopharyngeal carcinoma (NPC) cell line (5-8F NPC), treatment of DIM decreased the ability of cell migration and invasion dose-dependently. In rats, transplanted with NPC cells, DIM administration resulted in suppressing lymph node metastasis. Besides that, DIM was found to induce ERα target gene expression and the concomitant cell proliferation at low concentration (10μM) in the absence of E2 [1, 2 and 3].

References:
1. Ge X, Yannai S, Rennert G, et al. 3, 3′-Diindolylmethane induces apoptosis in human cancer cells. Biochemical and Biophysical Research Communications, 1996, 228(1): 153-158.
2. Wu T, Chen C, Li F, et al. 3, 3' Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. Experimental and Therapeutic Medicine, 2014, 7(6): 1635-1638.
3. Marques M, Laflamme L, Benassou I, et al. Low levels of 3, 3 [prime]-diindolylmethane activate estrogen receptor alpha and induce proliferation of breast cancer cells in the absence of estradiol. BMC cancer, 2014, 14(1): 524.

Physical Appearance

A solid

Chemical Properties

StorageStore at -20°C
M.Wt246.31
Cas No.1968-05-4
FormulaC17H14N2
Synonymsdiindolylmethane, 3,3'-Methylenediindole,DIM,Arundine,HB236
Solubility≥11.15 mg/mL in DMSO, ≥21.65 mg/mL in EtOH with ultrasonic and warming, <2.29 mg/mL in H2O
Chemical Name3-(1H-indol-3-ylmethyl)-1H-indole
SDFDownload SDF
Canonical SMILESC1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Biological Activity

Description DIM (3,3'-diindolylmethane) is a small molecule cancer preventive agent.
Targets apoptosis inducer          
IC50            

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