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3,3'-Diindolylmethane
Anticancer and antineoplastic agent

Catalog No.A3118
Size Price Stock Qty
10mM (in 1mL DMSO)
$50.00
In stock
100mg
$50.00
In stock
1g
$160.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Chemical structure

3,3

Biological Activity

Description DIM (3,3'-diindolylmethane) is a small molecule cancer preventive agent.
Targets apoptosis inducer          
IC50            

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Chemical Properties

Cas No. 1968-05-4 SDF Download SDF
Synonyms diindolylmethane, 3,3'-Methylenediindole,DIM,Arundine,HB236
Chemical Name 3-(1H-indol-3-ylmethyl)-1H-indole
Canonical SMILES C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43
Formula C17H14N2 M.Wt 246.31
Solubility >11.2mg/mL in DMSO Storage Store at -20°C
Shipping Condition Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

3,3'-Diindolylmethane is an anticancer agent [1].

3,3'-Diindolylmethane (DIM) is a dimer of indole-3-carbinol generated in low pH environment. It inhibited cell growth with IC50 values of 17, 24 and 30 μM in MCF-7, T47D and Saos2 cell lines, respectively. DIM induced apoptosis in these cells without affecting the p53 pathway. In human nasopharyngeal carcinoma (NPC) cell line (5-8F NPC), treatment of DIM decreased the ability of cell migration and invasion dose-dependently. In rats, transplanted with NPC cells, DIM administration resulted in suppressing lymph node metastasis. Besides that, DIM was found to induce ERα target gene expression and the concomitant cell proliferation at low concentration (10μM) in the absence of E2 [1, 2 and 3].

References:
1. Ge X, Yannai S, Rennert G, et al. 3, 3′-Diindolylmethane induces apoptosis in human cancer cells. Biochemical and Biophysical Research Communications, 1996, 228(1): 153-158.
2. Wu T, Chen C, Li F, et al. 3, 3' Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. Experimental and Therapeutic Medicine, 2014, 7(6): 1635-1638.
3. Marques M, Laflamme L, Benassou I, et al. Low levels of 3, 3 [prime]-diindolylmethane activate estrogen receptor alpha and induce proliferation of breast cancer cells in the absence of estradiol. BMC cancer, 2014, 14(1): 524.