Immunology/Inflammation - Cancer
The innate immune system is triggered when microbial pathogens are targeted by pattern recognition receptors such as Toll-like receptors (TLRs) that recognize the pathogen-associated molecular patterns. The activated TLRs initiate a cascade of interaction between various intracellular signaling adaptors including MyD88, IRAKs, and TRAF6, resulting the activation of the MAP kinase, NF-κB, and IRF signaling pathways, which mediate inflammation through the production of inflammatory cytokines, chemokines, type I IFN, and antimicrobial peptides.
The adaptive immune system consists of B and T lymphocytes which mediate humoral immunity (e.g. antibody response) and cell-mediated immunity, respectively. B cell receptor and T cell receptor signaling is responsible for activation of Src family tyrosine kinases, such as Blk, Fyn, and Lyn in B cells and Fyn and Lck in T cells, resulting phosphorylation of the receptor-associated ITAM motifs. Phosphorylated ITAMs serve as the docking sites for Syk family tyrosine kinases, e.g. Syk in B cells and Zap-70 in T cells. Activated Syk kinases then propagate the signals via phosphorylation of downstream proteins. Furthermore, lymphocyte receptor signaling facilitates B and T cell development, differentiation, proliferation and survival.
- B5638 ACHPSummary: IκB kinase inhibitor
- B6422 Pyrrolidinedithiocarbamate ammonium1 CitationSummary: NF-κB inhibitor
- B1587 IMD 03541 CitationSummary: IKKβ inhibitor
- B1644 Caffeic Acid Phenethyl EsterSummary: NF-κB activation inhibitor
- A3392 EmodinTarget: CK2Summary: Naturally occurring anthraquinone,antiproliferative
- A3220 BardoxoloneTarget: COX|iNOSSummary: Once-a-day treatment for CKD
- A4210 Bay 11-7821 (BAY 11-7082)1 CitationSummary: IKK/NF-κB/TNFα inhibitor
- A2604 CelastrolTarget: ProteasomeSummary: Antioxidant, anti-inflammatory and immunosuppressive agent
- N1846 Tanshinone IIATarget: AP-1|MAGLSummary: Antioxidant and anti-inflammatory reagent