Bcl-2 Family - Bcr-Abl - Bcl-xl
Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
- B5846 Radotinib(IY-5511)Target: PDGFR|Bcr-AblSummary: Bcr-Abl tyrosine kinase inhibitor
- A3935 WEHI-53915 CitationTarget: Bcl-xlSummary: Bcl-xL inhibitor,potent and selective
- A4200 Apogossypolone (ApoG2)2 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2 inhibitor,nonpeptidic small molecule
- A4234 TW-371 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1