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Signaling Pathways

Items 11-20 of 80

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  1. Indoximod (NLG-8189)
    B4900 Indoximod (NLG-8189)
    Summary: Indoleamine 2,3-dioxygenase (IDO) pathway inhibitor
      insoluble in DMSO; insoluble in EtOH; ≥1.12 mg/mL
  2. GSK 2837808A
    B4929 GSK 2837808A
    Target: Lactate Dehydrogenases (LDH)
    Summary: Potent, selective lactate dehydrogenase A (LDHA) inhibitor
      ≥9.12 mg/mL
  3. 7-Ethoxyresorufin
    B5963 7-Ethoxyresorufin
    Target: Cytochrome P450 (CYP450)
    Summary: Specific subtrate of CYP1A
      Soluble in DMSO
  4. CBR-5884
    A8721 CBR-5884
     1 Citation
    Target: 3-phosphoglycerate dehydrogenase
    Summary: selective inhibitor of PHGDH
      insoluble in EtOH; insoluble in H2O; ≥16.8 mg/mL
  5. GSK180
    A8723 GSK180
    Target: Kynurenine-3-monooxygenase
    Summary: inhibitor of kynurenine-3-monooxygenase (KMO)
      ≥27.6 mg/mL
  6. INCB-024360
    B6036 INCB-024360
    Target: IDO
    Summary: potent and selective inhibitor of IDO1
      insoluble in H2O; ≥17.1 mg/mL
  7. Pioglitazone
    B2117 Pioglitazone
    Summary: PPAR agonist
      insoluble in H2O; insoluble in EtOH; ≥14.3 mg/mL
  8. Fenofibrate
    B1943 Fenofibrate
     1 Citation
    Summary: PPARα agonist
      insoluble in H2O; ≥12.75 mg/mL
  9. A939572
    B3607 A939572
     1 Citation
    Target: Stearoyl-CoA 9-desaturase (SCD-1)
    Summary: Stearoyl-CoA desaturase1 (SCD1) inhibitor
      insoluble in H2O; ≥17.15 mg/mL
  10. LB42708
    B3703 LB42708
    Target: Ftase
    Summary: Selective FTase inhibitor
      ≥22.75 mg/mL

Items 11-20 of 80

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Category
  1. PPAR10item
  2. Aminopeptidase1 item
  3. Carbonic Anhydrase3item
  4. CETP2item
  5. CYP3A/CYP4502item
  6. Dehydrogenase5item
  7. DHFR1 item
  8. DGAT1 item
  9. Dopamine β-hydroxylase3item
  10. FAAH1 item
  11. Factor Xa1 item
  12. Ferroptosis1 item
  13. HMG-CoA Reductase5item
  14. HSP10item
  15. IDO3item
  16. KRAS-PDEδ1 item
  17. Lipid Metabolism1 item
  18. Neuronal Metabolism1 item
  19. P4503item
  20. PDE13item
  21. Phospholipase2item
  22. SCD1 item
  23. SGLT1 item
  24. Transferase7item
  25. monooxygenase1 item
Reversibility
  1. Reversible1 item
  2. Irreversible5item
Target
  1. Acyl coenzyme A: cholesterol acyltransferases1 item
  2. Factor Xa1 item
  3. Phosphodiesterases (PDEs)11item
  4. 3-phosphoglycerate dehydrogenase1 item
  5. Kynurenine-3-monooxygenase1 item
  6. RARs1 item
  7. Aminopeptidases1 item
  8. Stearoyl-CoA 9-desaturase (SCD-1)1 item
  9. HSP907item
  10. Cytochrome P450 (CYP450)4item
  11. Ferroptosis1 item
  12. HMG-CoA Reductases5item
  13. SGLT1 item
  14. DGAT2item
  15. Insulin and Insulin-like Receptors1 item
  16. CETP2item
  17. Lactate Dehydrogenases (LDH)2item
  18. Fatty-acid-binding proteins (FABPs)1 item
  19. Folate Analogue1 item
  20. IDH21 item
  21. Nampt1 item
  22. Carbonic Anhydrases3item
  23. Aldehyde Dehydrogenases2item
  24. Phospholipases1 item
  25. Catechol O-Methyltransferase (COMT)1 item
  26. FPTase1 item
  27. PPAR2item
  28. Ftase1 item
  29. FAAH1 item
  30. IDO1 item
  31. Glycogen Phosphorylases1 item
Reported Experiments
  1. Animal Experiments75item
  2. Cell Experiments54item
Related Disease
  1. Acne1 item
  2. Acute Myelogenous Leukemia1 item
  3. Acute Myeloid Leukemia2item
  4. Bladder Carcinoma1 item
  5. Brain Injuries Studies1 item
  6. Breast Cancer10item
  7. Cancer30item
  8. Cervical Cancer1 item
  9. Chronic Lymphocytic Leukemia1 item
  10. Cocaine-Related Disorders2item
  11. Colon Cancer1 item
  12. Diabetes2item
  13. Dyslipidemia1 item
  14. Epilepsy1 item
  15. Erectile Dysfunction3item
  16. Glioblastoma1 item
  17. Glioma1 item
  18. Hepatic Cancer1 item
  19. HIV Infections1 item
  20. Hypercholesterolemia2item
  21. Inflammation1 item
  22. Inflammatory Diseases2item
  23. Leukemia2item
  24. Lung Cancer5item
  25. Lymphoma3item
  26. Melanoma9item
  27. Multiple Myeloma3item
  28. Neuroblastoma3item
  29. Neurocognitive Disorders1 item
  30. Non-small Cell Lung Cancer2item
  31. Obsessive-Compulsive Disorder1 item
  32. Osteoporosis1 item
  33. Pancreatic Cancer2item
  34. Pancreatic Carcinoma1 item
  35. Prostate Cancer7item
  36. Psoriasis3item
  37. Psoriasis Vulgaris1 item
  38. Pulmonary Arterial Hypertension1 item
  39. Rheumatoid Arthritis2item
  40. Schizophrenia2item
  41. Type 2 Diabetes5item