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  • Search results for: 'signaling pathways membrane transporter ion channel cftr AND select 5033'

Search results for: 'signaling pathways membrane transporter ion channel cftr AND select 5033'

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  1. LDE225 (NVP-LDE225,Erismodegib)
    B2266 LDE225 (NVP-LDE225,Erismodegib)
     1 Citation
    Target: Smoothened
    Summary: Smoothened inhibitor,potent and selective
      ≥24.3 mg/mL
  2. ZM 447439
    A4113 ZM 447439
    Target: Aurora Kinases|MEK|Src|Lck
    Summary: Aurora Kinase inhibitor,potent and selective
      ≥25.7 mg/mL
      <2.2 mg/mL
      <1.24 mg/mL
  3. Cyclopamine
    A8340 Cyclopamine
     1 Citation
    Target: Smoothened
    Summary: Hedgehog (Hh) signaling Inhibitor
      ≥6.9 mg/mL
  4. LY2784544
    A4147 LY2784544
    Target: Aurora Kinases|FLT3|VEGFR|FGFR|Trk Receptors|JAK|ALK|TYK2|MUSK|MAP3K
    Summary: JAK2 inhibitor,highly potent and selective
      ≥23.5 mg/mL
      ≥5.65 mg/mL
      <2.37 mg/mL
  5. SNS-314 Mesylate
    A4121 SNS-314 Mesylate
    Target: Aurora Kinases
    Summary: Aurora A/B/C kinases inhibitor, potent and selective
      ≥26.35 mg/mL
      <2.37 mg/mL
      <2.15 mg/mL
  6. Barasertib (AZD1152-HQPA)
    A4112 Barasertib (AZD1152-HQPA)
     3 Citation
    Target: Aurora Kinases
    Summary: Aurora Kinase B inhibitor, Potent and selective
      ≥25.4 mg/mL
      <2.27 mg/mL
      <2.28 mg/mL
  7. AZD1152
    A3214 AZD1152
     1 Citation
    Target: Aurora Kinases
    Summary: Aurora B kinase inhibitor,highly potent and selective
      ≥5.88 mg/mL
      <2.46 mg/mL
      <2.25 mg/mL
  8. GSK1070916
    A4127 GSK1070916
    Target: Aurora Kinases
    Summary: Aurora B/C inhibitor
      ≥25.4 mg/mL
  9. PHA-680632
    A4122 PHA-680632
    Target: Aurora Kinases|PLK|FGFR
    Summary: Aurora kinase inhibitor,novel and potent
      ≥50.2 mg/mL
      <2.58 mg/mL
      <2.62 mg/mL
  10. ENMD-2076
    A4130 ENMD-2076
    Target: Aurora Kinases|FLT3|RET|Src|VEGFR3/FLT4|NTRK1/TRKA|CSF-1R/c-Fms
    Summary: Selective Aurora A/Flt3 inhibitor
      ≥18.75 mg/mL
      ≥2.55 mg/mL
      <2.3 mg/mL

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Category
Specificity
  1. Selective 18 items
Reversibility
  1. Reversible 2 items
Target
  1. Caspases 11 items
  2. Cyclin-Dependent Kinases 29 items
  3. Adenosine A2A Receptors 5 items
  4. Proteasome 11 items
  5. Cathepsins 12 items
  6. Histone Deacetylases (HDACs) 35 items
  7. Inhibitor of apoptosis proteins (IAP) 2 items
  8. Akt 13 items
  9. Bcl-2 7 items
  10. PI3K 34 items
  11. CXCR 6 items
  12. Raf 12 items
  13. Aurora Kinases 24 items
  14. Bcl-xl 3 items
  15. CSF-1R 3 items
  16. Glycoproteins 2 items
  17. Gap Junctions 2 items
  18. MDM2 3 items
  19. EZH2 5 items
  20. mTOR 21 items
  21. Bromodomains 8 items
  22. AP-1 3 items
  23. MMP 9 items
  24. Androgen Receptors 6 items
  25. Peptidylprolyl isomerases 1 item
  26. DT-diaphorases 1 item
  27. Voltage-gated Potassium (KV) Channels 5 items
  28. MER 1 item
  29. FLT3 18 items
  30. GSK-3 11 items
  31. Factor Xa 4 items
  32. Farnesoid X receptors (FXRs) 2 items
  33. LPA Receptors 4 items
  34. P-glycoprotein (P-gp) 5 items
  35. PLK 8 items
  36. Chk 8 items
  37. Eph Receptors 2 items
  38. VEGFR 35 items
  39. PDGFR 25 items
  40. c-Kit 11 items
  41. RET 3 items
  42. IRAK 1 item
  43. Bromodomain-containing proteins(BRDs) 1 item
  44. Phosphodiesterases (PDEs) 17 items
  45. Mcl-1 5 items
  46. Hydrolase 1 item
  47. Thymidylate Synthase 2 items
  48. p38 10 items
  49. PKB 1 item
  50. 3-phosphoglycerate dehydrogenase 1 item
  51. JNK 7 items
  52. SGK 2 items
  53. Bcr-Abl 15 items
  54. Kynurenine-3-monooxygenase 1 item
  55. MEK 16 items
  56. PORCN 1 item
  57. DOT1L 3 items
  58. FGFR 14 items
  59. Nrf2 2 items
  60. Insulin-like growth factor receptors(IGFRs) 1 item
  61. CGRP receptors 2 items
  62. Pim 4 items
  63. GABAB Receptors 1 item
  64. Liver X receptors (LXRs) 3 items
  65. Glucagon-like peptide 1 (GLP-1) receptors 1 item
  66. Sir2-like Family Deacetylases (Sirtuins) 5 items
  67. Voltage-gated Sodium (NaV) Channels 9 items
  68. Deubiquitinating enzymes (DUBs) 4 items
  69. PP1 1 item
  70. PP2A 1 item
  71. Smoothened 3 items
  72. Eukaryotic elongation factors 1 item
  73. Ribosomal s6 kinases (RSK) 1 item
  74. Neuraminidases (NA) 1 item
  75. MET 7 items
  76. Ras 1 item
  77. Src 15 items
  78. RARs 8 items
  79. Trk Receptors 6 items
  80. Integrins 1 item
  81. Aminopeptidases 4 items
  82. NMDA Receptors 2 items
  83. STAT 12 items
  84. Endothelin receptors 1 item
  85. Microtubules/Tubulins 4 items
  86. Estrogen and Related Receptors 8 items
  87. EGFR 23 items
  88. Hedgehog 1 item
  89. Reverse Transcriptases 3 items
  90. ROCK 11 items
  91. BTK 1 item
  92. RIP kinases 1 item
  93. Monocyte chemotactic proteins 1 item
  94. PAK 2 items
  95. Hypoxia Inducible Factors (HIFs) 2 items
  96. Tankyrases 1 item
  97. sulfhydryls (-SH) 1 item
  98. FAK 5 items
  99. BMP and Other Activin Receptors 4 items
  100. JAK 19 items
  101. p300 1 item
  102. Stearoyl-CoA 9-desaturase (SCD-1) 2 items
  103. Syk 5 items
  104. Progesterone Receptors 1 item
  105. EZH1 2 items
  106. DNA-PK 8 items
  107. HSP90 8 items
  108. AMPK 2 items
  109. CCR 3 items
  110. PDHK 1 item
  111. Angiotensin AT2 Receptors 2 items
  112. Notch 1 item
  113. S-nitrosoglutathione reductase 1 item
  114. CFTR 4 items
  115. TNKS 1 item
  116. Topoisomerases 10 items
  117. Cytochrome P450 (CYP450) 15 items
  118. M3 Receptors 2 items
  119. Ksp 1 item
  120. Renin 1 item
  121. HIV proteases 1 item
  122. Pepsins 1 item
  123. Influenza viruses 1 item
  124. ErbB 4 items
  125. Ferroptosis 1 item
  126. Toll-like receptors (TLRs) 3 items
  127. Actin 3 items
  128. DNA Methyltransferases 4 items
  129. Epac 1 item
  130. ERK 6 items
  131. HMG-CoA Reductases 2 items
  132. c-MET 9 items
  133. BMI-1 1 item
  134. PKC 15 items
  135. Calpains 6 items
  136. Ubiquitin-specific proteases 1 item
  137. M1 Receptors 1 item
  138. HCV Proteases 2 items
  139. Ca2 /calmodulin-dependent protein kinases (CaMKs) 5 items
  140. MLK3 1 item
  141. SMYD2 1 item
  142. O-GlcNAcase 1 item
  143. CREBBP 2 items
  144. EP300 2 items
  145. Protease-Activated Receptors 2 items
  146. Lyn 2 items
  147. SGLT 2 items
  148. Trypsins 1 item
  149. HER2 2 items
  150. Pyk2 3 items
  151. USP 2 items
  152. 5-HT2 Receptors 8 items
  153. LRRK2 6 items
  154. Calcium ionophores 1 item
  155. S1P receptors 1 item
  156. Voltage-gated Calcium Channels (CaV) 15 items
  157. Calcium chelator 1 item
  158. DGAT 2 items
  159. Insulin and Insulin-like Receptors 5 items
  160. Mitochondrial apoptosis-induced channel (MAC) 1 item
  161. PARP 5 items
  162. CB1 Receptors 3 items
  163. Pyruvate dehydrogenases (PDH) 1 item
  164. ALK 8 items
  165. ROS1 1 item
  166. Sphingosine kinases (SphKs) 2 items
  167. Trypsin 1 item
  168. Chymotrypsin 1 item
  169. Kallikrein 1 item
  170. Trypsinogen 1 item
  171. KRAS G12C 1 item
  172. GTPases 1 item
  173. Monocarboxylate transporters (MCTs) 2 items
  174. CETP 2 items
  175. Dehydrogenase 1 item
  176. PKG 2 items
  177. PKA 6 items
  178. Myosin light chain kinases (MLCKs) 1 item
  179. GPR30 1 item
  180. HIV-1 gp120 1 item
  181. D1 and D5 Receptors 2 items
  182. D2 Receptors 7 items
  183. D3 Receptors 3 items
  184. 5-HT1 Receptors 6 items
  185. 5-HT7 Receptors 2 items
  186. Valosin-containing protein (VCP) 1 item
  187. AdipoR1 1 item
  188. AdipoR2 2 items
  189. Serotonin reuptake 1 item
  190. AMPA 1 item
  191. Clk 1 item
  192. TBK1 1 item
  193. MARK1 1 item
  194. NUAK1 2 items
  195. Bromodomain and Extra-Terminal motif (BET) 1 item
  196. NUAK2 1 item
  197. Na /H Exchangers (NHEs) 1 item
  198. Lactate Dehydrogenases (LDH) 1 item
  199. MK2 3 items
  200. Fatty-acid-binding proteins (FABPs) 1 item
  201. 5-HT3 Receptors 5 items
  202. Angiotensin-Converting Enzymes (ACEs) 1 item
  203. Tie-2 4 items
  204. RSK 2 items
  205. Granzyme B 1 item
  206. Free Fatty Acid Receptors 2 items
  207. phosphatases 3 items
  208. ROS and Other Gaseous Donors 1 item
  209. Autophagy 4 items
  210. ATM/ATR 6 items
  211. COX 14 items
  212. C5a receptors 1 item
  213. CK1 2 items
  214. IDH2 1 item
  215. Histamine H4 Receptors 1 item
  216. Farnesyl Diphosphate Synthases 1 item
  217. CK2 3 items
  218. HIPK2 1 item
  219. HIPK3 1 item
  220. HIV Integrases 1 item
  221. Pregnane X Receptors 1 item
  222. Squalene epoxidases 2 items
  223. Delayed rectifier outward potassium current (IKr) 1 item
  224. Melatonin Receptors 1 item
  225. 20S proteasomal chymotrypsin 1 item
  226. Geranylgeranyltransferase I 1 item
  227. Farnesyltransferase 1 item
  228. Nampt 2 items
  229. eIF4F 1 item
  230. Cdc42 1 item
  231. SRPK1 1 item
  232. P2X Receptors 2 items
  233. Carbonic Anhydrases 3 items
  234. Ron 1 item
  235. AP endonucleases 1 item
  236. G9a 2 items
  237. BLM 1 item
  238. HSV 2 items
  239. NADPH Oxidases 3 items
  240. Glutamate (Metabotropic) Group I Receptors 1 item
  241. Calcium-activated chloride channels (CaCC) 1 item
  242. GPR35 1 item
  243. Urokinases 2 items
  244. Synthases/Synthetases 3 items
  245. MAGL 2 items
  246. NPY Receptors 2 items
  247. c-Fyn 1 item
  248. Leukotriene and Related Receptors 1 item
  249. Histamine H1 Receptors 10 items
  250. RAR/RXR 2 items
  251. Sigma Receptors 1 item
  252. Na /K ATPases 1 item
  253. P110 1 item
  254. Hck 2 items
  255. Inositol-requiring enzyme 1 (IRE1) 1 item
  256. SETD7 1 item
  257. GABAA Receptors 3 items
  258. Opioid receptors 1 item
  259. Phospholipases 1 item
  260. Monoamine oxidases (MAOs) 1 item
  261. Organic anion transporters (OATs) 1 item
  262. TRP Channel 3 items
  263. RNA Polymerases 2 items
  264. DYRK 2 items
  265. Norepinephrine transporter 1 item
  266. 5-HT Transporters 3 items
  267. Ionophores 2 items
  268. Xanthine oxidoreductases 1 item
  269. Dihydroorotate dehydrogenase 1 item
  270. Histone Demethylases 2 items
  271. Apoptosis Inducers 1 item
  272. M2 Receptors 1 item
  273. MNK 2 items
  274. 5-Lipoxygenases 2 items
  275. NO Donors / Precursors 2 items
  276. CB2 Receptors 3 items
  277. Glucocorticoid Receptors 5 items
  278. Adenosine A1 Receptors 1 item
  279. IL Receptors 2 items
  280. CCL2 1 item
  281. Noradrenaline reuptake 1 item
  282. Norepinephrine transporters 1 item
  283. 15-lipoxygenases 1 item
  284. Calcium-Activated Potassium (KCa) Channels 4 items
  285. 5-HT4 Receptors 1 item
  286. AChE 2 items
  287. Insulin Receptors 1 item
  288. IRG-1R 1 item
  289. Proton Pump 1 item
  290. cAMP 1 item
  291. Sulfonylurea receptors 1 item
  292. Cdc2-like kinase (Clk) 1 item
  293. eEF-2 1 item
  294. Inward Rectifier Potassium (Kir) Channels 6 items
  295. Arp2/3 complex 1 item
  296. Peptidoglycan synthesis 1 item
  297. Tetrahydrofolate dehydrogenase 1 item
  298. CRTH2 1 item
  299. Cdc7 2 items
  300. ZAP-70 1 item
  301. Catechol O-Methyltransferase (COMT) 2 items
  302. fibrinolysis 1 item
  303. Angiotensin AT1 Receptors 1 item
  304. D4 Receptors 2 items
  305. NMDA receptor 1 item
  306. Aldosterone receptor 1 item
  307. M4 Receptors 1 item
  308. M5 Receptors 1 item
  309. Hydroxylases 2 items
  310. Flk-1 1 item
  311. Adenine receptors 1 item
  312. Antioxidants 3 items
  313. Papains 1 item
  314. RNA synthesis 1 item
  315. Na /Ca2 Exchangers (NCXs) 1 item
  316. NAE 2 items
  317. Ubiquitin-activating Enzyme E1 1 item
  318. SUMOylation 1 item
  319. ATGL 1 item
  320. BACE 2 items
  321. Cytidine deaminases 1 item
  322. GPR40 1 item
  323. Adenylyl Cyclases 1 item
  324. angiogenesis 1 item
  325. Glucagon Receptors 1 item
  326. 15-PGDH 1 item
  327. DPP-4 3 items
  328. PP4 1 item
  329. c-RET 2 items
  330. Nonstructural protein 5B (NS5B) 1 item
  331. ETA Receptors 1 item
  332. p70 rsk 3 items
  333. voltage-gated chloride channels 1 item
  334. FPTase 1 item
  335. AChR 5 items
  336. Retinoic acid-related Orphan Receptors (RORs) 1 item
  337. 5-HT1 Receptor 1 item
  338. Microtubule/Tubulin 1 item
  339. Myosin 1 item
  340. VEGFR3/FLT4 1 item
  341. NTRK1/TRKA 1 item
  342. CSF-1R/c-Fms 1 item
  343. interleukin receptor 1 item
  344. ADAMs 1 item
  345. Bfl-1 1 item
  346. TAM kinase 1 item
  347. sodium channels 1 item
  348. p53-MDM2 interaction 1 item
  349. nuclear export 1 item
  350. CRM1 1 item
  351. PTP 1 item
  352. endothelin receptor 1 item
  353. KDR 2 items
  354. Abl kinases 1 item
  355. Trypsin-like protease 1 item
  356. Protein polybromo-1 1 item
  357. SMARCA4 1 item
  358. SMARCA2 1 item
  359. ERAD 1 item
  360. p53 6 items
  361. adrenoceptor 2 items
  362. HDAC 2 items
  363. Antifungal 1 item
  364. KDM 2 items
  365. LOX 1 item
  366. Adenylyl cyclase 1 item
  367. Quinone reductase 1 item
  368. 5-HT receptors 1 item
  369. sodium channel 4 items
  370. c-Fms tyrosine kinase 1 item
  371. PAR 1 item
  372. human lyase 1 item
  373. insulin 1 item
  374. Ub-conjugating enzyme (E2) complex 1 item
  375. Smoothened receptor 1 item
  376. lipase 1 item
  377. cysteine protease 1 item
  378. Nrf2/ARE signal 1 item
  379. PPAR 4 items
  380. haspin kinase 1 item
  381. HDM2 ubiquitin ligase 1 item
  382. IKK 1 item
  383. GABA receptors 1 item
  384. MSK 1 item
  385. prostaglandin FP receptor 1 item
  386. HCV polymerase 2 items
  387. Ftase 1 item
  388. PC-PLC 2 items
  389. Elastases 1 item
  390. GK 1 item
  391. P97 ATPase 1 item
  392. Vitamin D receptors (VDRs) 2 items
  393. Antibiotic 3 items
  394. Mer tyrosine kinase 1 item
  395. cannabinoid receptor 1 item
  396. Calcium-Sensing Receptors (CaSRs) 1 item
  397. DNA Alkylating 1 item
  398. GLI 1 item
  399. ErbB-2 1 item
  400. adrenergic receptor 4 items
  401. HIV 1 item
  402. 5-HT4 Receptor 1 item
  403. TRPA 1 item
  404. sterol demethylase 1 item
  405. telomerase 1 item
  406. Histone Acetyltransferases (HATs) 2 items
  407. Retinoid X receptors (RXR) 1 item
  408. constitutive androstane receptor (CAR) 1 item
  409. NPFF receptor 1 item
  410. Prk 1 item
  411. potassium channel 1 item
  412. calcium channel 1 item
  413. Trx 1 item
  414. HSP70 1 item
  415. Pregnane X receptor(PXR) 1 item
  416. ICAM 1 item
  417. ITK 1 item
  418. NOD1 1 item
  419. NUAK 1 item
  420. Rho 1 item
  421. Aryl hydrocarbon receptors (AHRs) 1 item
  422. Ubiquitin E3 Ligases 1 item
  423. DCLK2 1 item
  424. FAAH 1 item
  425. PTK 1 item
  426. integrase 1 item
  427. L3MBTL 1 item
  428. phosphatidylinositol kinase 1 item
  429. NOS 1 item
  430. TYK2 1 item
  431. MUSK 1 item
  432. MAP3K 1 item
  433. GPR3 1 item
  434. AMPA Receptors 1 item
  435. Lck 1 item
  436. Adenosine Deaminases 1 item
  437. mitochondrial pyruvate carrier (MPC) 1 item
  438. SERT 1 item
  439. prolactin secretion 1 item
  440. gonadotropin release 1 item
  441. UCP 1 item
  442. DprE 1 item
  443. Vitamin D 1 item
  444. carnitine reabsorption 1 item
  445. Histamine receptors 1 item
  446. GluR 1 item
  447. 5-HT receptor 1 item
  448. dopamine receptors 1 item
  449. AMPA receptor 1 item
  450. Flk1 1 item
  451. SAPK 1 item
  452. p21 1 item
  453. DNA Ligases 1 item
  454. NOP Receptors 1 item
  455. Prostaglandin synthesis 1 item
  456. Protein Tyrosine Phosphatases 1 item
  457. alkaline phosphatases 1 item
  458. ATPases 1 item
  459. glutamate release 1 item
  460. PAFR 1 item
  461. Aromatases 2 items
  462. DHFR 1 item
  463. GARFT 1 item
  464. 5-HT 1 item
  465. PHF 1 item
  466. FGR 1 item
  467. YES 2 items
  468. Fyn 2 items
  469. ARG 1 item
  470. Autotaxin 1 item
  471. HCV NS3-4A protease 1 item
  472. TRPC channel 1 item
  473. PKD 1 item
  474. Pyruvate kinases 1 item
  475. P2Y Receptors 1 item
  476. enoyl-acyl-carrier protein reductase 1 item
  477. SHIP 1 item
  478. FKBP 1 item
  479. Bcl-w 1 item
  480. Rho-kinase 1 item
  481. LSD 1 item
  482. ACE 1 item
  483. GLP 1 item
  484. SK 1 item
  485. MST 1 item
  486. PPK 1 item
  487. c-Syk 1 item
  488. CDK1/CyclinB 1 item
  489. IDO 1 item
  490. FXR 1 item
  491. Cx43 1 item
  492. PIM1 kinase 1 item
  493. phospholipase A2 1 item
  494. reverse transcriptase 1 item
  495. epoxide hydrolase 1 item
  496. Serotonin (5-HT) reuptake 1 item
  497. Androgen Receptor 1 item
  498. Substance P/NK1 Receptor 1 item
  499. gp120/CD4 1 item
  500. ATM 2 items
  501. Sirtuin 1 item
  502. PIKfyve 1 item
  503. Glycogen Phosphorylases 1 item
  504. RGS 1 item
  505. MTH1 1 item
  506. PTEN 1 item
  507. Insulin Receptor 1 item
  508. p90 S6K 1 item
Reported Experiments
  1. Animal Experiments 25 items
  2. Cell Experiments 21 items
Related Disease
  1. Acute Myeloid Leukemia 2 items
  2. Breast Cancer 5 items
  3. Cancer 22 items
  4. Cervical Cancer 1 item
  5. Colon Cancer 4 items
  6. Colorectal Cancer 3 items
  7. Glioma 2 items
  8. Leukemia 2 items
  9. Lung Cancer 3 items
  10. Lymphoma 1 item
  11. Medulloblastoma 1 item
  12. Multiple Myeloma 2 items
  13. Ovarian Cancer 3 items
  14. Pancreatic Cancer 3 items
  15. Pancreatic Carcinoma 1 item
  16. Prostate Cancer 2 items
  17. Renal Cell Carcinoma 1 item
  18. Thyroid Cancer 1 item