Search results for: 'signaling pathways membrane transporter ion channel cftr AND select 5033'
- CyclopamineCatalog No. :A8340Hedgehog (Hh) signaling Inhibitor
Cyclopamine is a naturally occurring Hedgehog (Hh)‑specific small‑molecule signaling steroidal alkaloid inhibitor, causes a profound inhibition of tumor growth, has significant anti‑invasive, anti‑proliferative and anti‑estrogenic potency in human breast cancer cells  .
- LDE225 (NVP-LDE225,Erismodegib)Catalog No. :B2266Smoothened inhibitor,potent and selective
LDE225 is a potent and selective inhibitor of smoothened with IC50 values of 1.3nM in mouse and 2.5nM in human, respectively .
- BMS-833923Catalog No. :A3258Smoothened inhibitor
BMS-833923 is an orally bioavailable and selective antagonist of smoothened (SMO) with IC0 value of 5.8 nM in NIH3T3 cell line .