Search results for: 'signaling pathways membrane transporter ion channel cftr AND select 5033'
- Nilotinib(AMN-107)Catalog No. :A8232Bcr-Abl kinase inhibitor,selective
Nilotinib is a selective, oral inhibitor of tyrosine kinase with IC50 values of 20, 42, 31, 38, 29 and 41 nM for the autophosphorylation of native BCR-ABL (WT p210) and mutant BCR-ABL (E281K, E292K, F317L, M351T and F486S), respectively .
- Imatinib (STI571)Catalog No. :B2171Protein-tyrosine kinase inhibitorImatinib is an inhibitor of protein-tyrosine kinase with IC50 values of 0.1, 0.1 and 0.025μM, respectively against PDGF receptor, c-Kit and Abl .
- CP-724714Catalog No. :A2412HER2 inhibitor,potent and selectiveCP-724714 is an inhibitor of erbB2 and EGFR kinases with IC50 values of 10±3 nmol/L and 6,400±2,100 nmol/L, respectively .
- GNF 5Catalog No. :A8604Bcr-Abl inhibitorGNF-5 is a potent, selective, non-ATP competitive allosteric inhibitor of Bcr-Abl with IC50 value of 220 nM.
- PP121Catalog No. :B2172Dual inhibitor of tyrosine and phosphoinositide kinasesPP121 is a dual inhibitor of tyrosine and phosphoinositide kinases .
- Ponatinib (AP24534)Catalog No. :A5467pan-BCR-ABL inhibitor,multi-kinase inhibitorPotent multi-kinase and pan-BCR-ABL inhibitor.
- KW 2449Catalog No. :A4123Multikinase inhibitorKW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase with IC50 values of 6.6nM, 14nM, 4nM and 48nM, respectively .
- Radotinib(IY-5511)Catalog No. :B5846Bcr-Abl tyrosine kinase inhibitorRadotinib(IY-5511) is a novel and selective Bcl-Abl tyrosine kinase inhibitor. 
- 1-NM-PP1Catalog No. :B1299Pp60c-src inhibitor1-NM-PP1 is a C3-modified analog of cell-permeable PP1, acts as a potent and selective inhibitor of protein kinase families .
- DCC-2036 (Rebastinib)Catalog No. :B1404Bcr-Abl inhibitorDCC-2036 is a conformational control inhibitor of ABL1 with IC50 value of 0.8nM .