Search results for: 'signaling pathways membrane transporter ion channel cftr AND select 5033'
- EntacaponeCatalog No. :A4168COMT inhibitorEntacapone is a second-generation catechol-O-methyltransferase (COMT) inhibitor that potently inhibits rat liver total COMT with the half maximal inhibition concentration IC50 and inhibition constant Ki values of 20.1 nM and 10.7 nM respectively. The IC50 values of entacapone against rate liver soluble COMT (S-COMT) and rat liver membrane-bound COMT (MB-COMT) are 14.3 nM and 73.3 nM respectively .
- Thioridazine HClCatalog No. :A8537Calcium channel protein inhibitorThioridazine·HCl is a calcium channel protein inhibitor as well as D2DR/D4DR inhibitor.
- FenoldopamCatalog No. :B1483D1-like dopamine receptor partial agonistSelective D1-like dopamine receptor partial agonist (EC50 = 57 nM).
- TolcaponeCatalog No. :A4383COMT inhibitor
Tolcapone is a novel, reversible and orally-bioavailable small-molecule catechol-O-methyltransferase (COMT) inhibitor used for as an adjunct to levodopa therapy for the treatment of Parkinson’s disease (PD).