Search results for: 'signaling pathways membrane transporter ion channel cftr AND select 5033'
- Nutlin-3Catalog No. :A4228MDM2 antagonist,inhibits MDM2-p53 interaction
Nutlin-3, a tetra-substituted imidazoline, is a potent and selective small-molecule antagonist of murine double minute 2 (MDM2), which occupies the binding site of p53 in MDM2 and consequently prevent MDM2 binding to p53 leading to the disruption of the autoregulator feedback loop and the fostering of the p53 tumor suppressor network.
- RG7112Catalog No. :A3762MDM2 inhibitor, first clinical
RG7112 is a selective inhibitor of p53-MDM2 binding that frees p53 from negative control, activating the p53 pathway in cancer cells leading to cell cycle arrest and apoptosis. 
- ParthenolideCatalog No. :N1315Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)