Search results for: 'research-area tyrosine-kinase vegfr'
- Tie2 kinase inhibitorCatalog No. :A5979Tie-2(Tie2 ) inhibitor
Tie2 Kinase Inhibitor is a cell-permeable pyridinylimidazole which has been reported to act as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie-2(Tie2 )with a reported ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over Flk-1(VEGFR2), Flt-4 (VEGFR3), and PDGFR-β (PDGFR1&beta);.
- Pexmetinib (ARRY-614)Catalog No. :B6012dual inhibitor of p38 MAPK and Tie2/Tek receptor tyrosine kinase
- AltiratinibCatalog No. :B5832c-MET/TIE-2/VEGFR inhibitor
Altiratinib (DCC-2701) is a potent inhibitor of c-MET/TIE-2/VEGFR with IC50 values of 2.7, 8.0 and 9.2 nM, respectively .