Search results for: 'research-area gpcr-g-protein nop-receptor'
- Dovitinib (TKI-258, CHIR-258)Catalog No. :A2168Multitargeted RTK inhibitor
Dovitinib (TKI258, CHIR-258) is a multitargeted receptor tyrosine kinase inhibitor against FLT3, KIT, FGFR, VEGFR, PDGFRα and PDGFRβ with IC50 of 1 nM, 2 nM, 8-9 nM, 8-13 nM , 210 nM and 27nM, respectively .
- Gefitinib (ZD1839)Catalog No. :A8219Selective EGFR inhibitor
Gefitinib, also known as ZD1839 or Iressa, is a potent and orally-bioavailable small-molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase with 50% inhibition concentration IC50 values of 0.033 μM and 0.027 μM in A431 membrane prep and baculovirus lysate respectively.
- Gefitinib hydrochlorideCatalog No. :A3433Potent EGFR inhibitor
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.
- AminophyllineCatalog No. :A4346Pan-PDE inhibitorAminophylline(Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.