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Search results for: 'all-target'

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  1. AKT inhibitor VIII
    A3149 AKT inhibitor VIII
     2 Citation
    Target: Akt
    Summary: Allosteric Akt kinase inhibitor
      ≥9.2 mg/mL
      insoluble in etoh
      insoluble in h2o
  2. AZD5363
    A1387 AZD5363
     3 Citation
    Target: Akt
    Summary: AKT inhibitor,pyrrolopyrimidine derived
      ≥21.45 mg/mL
  3. PP121
    B2172 PP121
    Target: mTOR|Eph Receptors|VEGFR|PDGFR|Bcr-Abl|Src|DNA-PK|P110|Hck
    Summary: Dual inhibitor of tyrosine and phosphoinositide kinases
      ≥15.95 mg/mL
  4. PTC-209
    B3179 PTC-209
    Target: BMI-1
    Summary: Bmi-1 inhibitor,cell-permeable and small-molecule
      ≥24.75 mg/mL
  5. PD173955
    A8812 PD173955
    Target: Bcr-Abl|Src
    Summary: Dual Src/Abl kinase inhibitor, ATP-competitive,
      ≥22.15 mg/mL
  6. CCT128930
    A8617 CCT128930
    Target: Akt
    Summary: AKT inhibitor
      ≥17.1 mg/mL
  7. A-674563
    A8616 A-674563
    Target: Cyclin-Dependent Kinases|Akt|GSK-3|ERK|PKC|PKA|RSK
    Summary: Akt1/PKA/CDK2 inhibitor,potent and selective
      ≥4.9 mg/mL
  8. PF-04691502
    A8499 PF-04691502
    Target: Akt|PI3K|mTOR
    Summary: PI3K/mTOR (FRAP) inhibitor
      ≥10.625 mg/mL
  9. Perifosine
    A8309 Perifosine
     1 Citation
    Target: Akt
    Summary: Akt inhibitor
      insoluble in dmso
      ≥5.55 mg/mL
      ≥5.94 mg/mL
  10. Butein
    A2689 Butein
    Target: Src|STAT|EGFR|Angiotensin-Converting Enzymes (ACEs)|5-Lipoxygenases|PTK|enoyl-acyl-carrier protein reductase
    Summary: Protein kinase inhibitor
      ≥13.6 mg/mL

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Category
Specificity
  1. Selective 12 items
Reversibility
  1. Reversible 2 items
Target
  1. Caspases 9 items
  2. Cyclin-Dependent Kinases 19 items
  3. Adenosine A2A Receptors 3 items
  4. Proteasome 6 items
  5. Cathepsins 10 items
  6. Histone Deacetylases (HDACs) 26 items
  7. Inhibitor of apoptosis proteins (IAP) 2 items
  8. Akt 10 items
  9. Bcl-2 7 items
  10. PI3K 23 items
  11. CXCR 4 items
  12. Raf 11 items
  13. Aurora Kinases 19 items
  14. Bcl-xl 3 items
  15. CSF-1R 2 items
  16. Glycoproteins 2 items
  17. Gap Junctions 3 items
  18. MDM2 2 items
  19. EZH2 4 items
  20. mTOR 16 items
  21. Bromodomains 8 items
  22. MMP 5 items
  23. Thymidine Phosphorylases 1 item
  24. Androgen Receptors 3 items
  25. Peptidylprolyl isomerases 1 item
  26. Acyl coenzyme A: cholesterol acyltransferases 1 item
  27. DT-diaphorases 1 item
  28. FLT3 13 items
  29. GSK-3 9 items
  30. Factor Xa 2 items
  31. Farnesoid X receptors (FXRs) 1 item
  32. LPA Receptors 3 items
  33. P-glycoprotein (P-gp) 4 items
  34. PLK 7 items
  35. Chk 4 items
  36. Eph Receptors 2 items
  37. VEGFR 30 items
  38. PDGFR 20 items
  39. c-Kit 8 items
  40. RET 4 items
  41. IRAK 3 items
  42. Bromodomain-containing proteins(BRDs) 1 item
  43. Phosphodiesterases (PDEs) 3 items
  44. Mcl-1 4 items
  45. Hydrolase 1 item
  46. Thymidylate Synthase 1 item
  47. p38 5 items
  48. PKB 1 item
  49. JNK 2 items
  50. SGK 1 item
  51. Bcr-Abl 11 items
  52. MEK 17 items
  53. PORCN 1 item
  54. DOT1L 2 items
  55. FGFR 12 items
  56. Nrf2 1 item
  57. Insulin-like growth factor receptors(IGFRs) 1 item
  58. CGRP receptors 2 items
  59. Pim 2 items
  60. Liver X receptors (LXRs) 2 items
  61. Sir2-like Family Deacetylases (Sirtuins) 3 items
  62. Voltage-gated Sodium (NaV) Channels 1 item
  63. Deubiquitinating enzymes (DUBs) 2 items
  64. Smoothened 3 items
  65. Ribosomal s6 kinases (RSK) 1 item
  66. MET 6 items
  67. Src 13 items
  68. RARs 1 item
  69. Trk Receptors 2 items
  70. Integrins 1 item
  71. Aminopeptidases 2 items
  72. NMDA Receptors 2 items
  73. STAT 5 items
  74. Microtubules/Tubulins 4 items
  75. EGFR 21 items
  76. Hedgehog 1 item
  77. Reverse Transcriptases 1 item
  78. ROCK 4 items
  79. BTK 1 item
  80. RIP kinases 1 item
  81. PAK 3 items
  82. sulfhydryls (-SH) 1 item
  83. FAK 6 items
  84. BMP and Other Activin Receptors 3 items
  85. JAK 16 items
  86. p300 1 item
  87. Stearoyl-CoA 9-desaturase (SCD-1) 1 item
  88. Syk 4 items
  89. EZH1 1 item
  90. DNA-PK 5 items
  91. HSP90 9 items
  92. Gutathione S-transferase 1 item
  93. CCR 2 items
  94. PDHK 1 item
  95. Angiotensin AT2 Receptors 1 item
  96. eIF4E/eIF3G interaction 1 item
  97. CFTR 3 items
  98. TNKS 1 item
  99. Topoisomerases 5 items
  100. Cytochrome P450 (CYP450) 3 items
  101. Ksp 1 item
  102. Ribosomes 1 item
  103. ErbB 4 items
  104. Ferroptosis 1 item
  105. Toll-like receptors (TLRs) 1 item
  106. Adenosine Kinases 1 item
  107. Serine Proteases 1 item
  108. DNA Methyltransferases 3 items
  109. Survivin 1 item
  110. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs) 1 item
  111. ERK 4 items
  112. HMG-CoA Reductases 1 item
  113. c-MET 7 items
  114. BMI-1 1 item
  115. PKC 9 items
  116. Calpains 4 items
  117. Ubiquitin-specific proteases 1 item
  118. HCV Proteases 2 items
  119. Ca2 /calmodulin-dependent protein kinases (CaMKs) 3 items
  120. CREBBP 2 items
  121. EP300 2 items
  122. Protease-Activated Receptors 2 items
  123. Lyn 1 item
  124. SGLT 1 item
  125. RAD51 1 item
  126. Trypsins 1 item
  127. HER2 2 items
  128. Pyk2 3 items
  129. LRRK2 3 items
  130. S1P receptors 2 items
  131. Calcium chelator 1 item
  132. DGAT 1 item
  133. Insulin and Insulin-like Receptors 5 items
  134. PARP 8 items
  135. CB1 Receptors 1 item
  136. Pyruvate dehydrogenases (PDH) 1 item
  137. ALK 7 items
  138. Sphingosine kinases (SphKs) 1 item
  139. Trypsin 1 item
  140. Chymotrypsin 1 item
  141. Kallikrein 1 item
  142. Trypsinogen 1 item
  143. KRAS G12C 1 item
  144. GTPases 1 item
  145. CETP 2 items
  146. Dehydrogenase 1 item
  147. PKG 1 item
  148. PKA 5 items
  149. HIV-1 gp120 1 item
  150. 5-HT1 Receptors 1 item
  151. 5-HT7 Receptors 1 item
  152. Valosin-containing protein (VCP) 1 item
  153. MELK 1 item
  154. Insulin-like growth factors (IGFs) 1 item
  155. AMPA 1 item
  156. Clk 1 item
  157. TBK1 1 item
  158. MARK1 1 item
  159. NUAK1 1 item
  160. Integrin-ligand interactions 1 item
  161. Bromodomain and Extra-Terminal motif (BET) 1 item
  162. MK2 1 item
  163. 5-HT3 Receptors 1 item
  164. Angiotensin-Converting Enzymes (ACEs) 1 item
  165. Tie-2 2 items
  166. RSK 1 item
  167. Free Fatty Acid Receptors 1 item
  168. phosphatases 2 items
  169. Autophagy 1 item
  170. ATM/ATR 6 items
  171. COX 1 item
  172. YAP 1 item
  173. IDH2 1 item
  174. HIV Integrases 2 items
  175. Squalene epoxidases 2 items
  176. Melatonin Receptors 1 item
  177. Nampt 1 item
  178. eIF4F 1 item
  179. Cdc42 1 item
  180. SRPK1 1 item
  181. P2X Receptors 2 items
  182. Ron 1 item
  183. G9a 1 item
  184. Histamine H1 Receptors 3 items
  185. RAR/RXR 1 item
  186. P110 1 item
  187. Hck 2 items
  188. GABAA Receptors 1 item
  189. Phospholipases 1 item
  190. TRP Channel 1 item
  191. Xanthine oxidoreductases 1 item
  192. Histone Demethylases 1 item
  193. MNK 1 item
  194. 5-Lipoxygenases 1 item
  195. Glucocorticoid Receptors 1 item
  196. Calcium-Activated Potassium (KCa) Channels 2 items
  197. AChE 2 items
  198. Insulin Receptors 1 item
  199. IRG-1R 1 item
  200. eEF-2 1 item
  201. Cdc7 1 item
  202. ZAP-70 1 item
  203. Angiotensin AT1 Receptors 1 item
  204. O6-methylguanine-DNA-methyl-transferase (MGMT) 1 item
  205. Antioxidants 2 items
  206. Papains 1 item
  207. Na /Ca2 Exchangers (NCXs) 1 item
  208. Ubiquitin-activating Enzyme E1 1 item
  209. BACE 3 items
  210. Cytidine deaminases 1 item
  211. GPR40 1 item
  212. angiogenesis 1 item
  213. Glucagon Receptors 1 item
  214. DPP-4 2 items
  215. c-RET 1 item
  216. Nonstructural protein 5B (NS5B) 1 item
  217. guanylyl cyclase 1 item
  218. p70 rsk 2 items
  219. FPTase 1 item
  220. AChR 1 item
  221. Microtubule/Tubulin 1 item
  222. Myosin 1 item
  223. VEGFR3/FLT4 1 item
  224. NTRK1/TRKA 1 item
  225. CSF-1R/c-Fms 1 item
  226. Tryptophan hydroxylases (TPH) 1 item
  227. Bfl-1 1 item
  228. p53-MDM2 interaction 2 items
  229. KDR 2 items
  230. Fyn kinase 1 item
  231. Glyoxalase I 1 item
  232. p53 6 items
  233. HDAC 1 item
  234. Antifungal 1 item
  235. c-Fms tyrosine kinase 1 item
  236. insulin 1 item
  237. Ub-conjugating enzyme (E2) complex 1 item
  238. Smoothened receptor 1 item
  239. cysteine protease 2 items
  240. PPAR 3 items
  241. HDM2 ubiquitin ligase 1 item
  242. IKK 1 item
  243. GABA receptors 1 item
  244. gp120-CD4 interaction 1 item
  245. HCV polymerase 3 items
  246. Lyn kinase 1 item
  247. Ftase 1 item
  248. PC-PLC 1 item
  249. GK 1 item
  250. P97 ATPase 1 item
  251. Glucosidases 1 item
  252. Vitamin D receptors (VDRs) 1 item
  253. Mer tyrosine kinase 1 item
  254. neprilysin 1 item
  255. Calcium-Sensing Receptors (CaSRs) 1 item
  256. GLI 1 item
  257. ErbB-2 1 item
  258. PAR receptor 1 item
  259. TRPA 1 item
  260. sterol demethylase 1 item
  261. PDK-1 1 item
  262. telomerase 1 item
  263. Prk 1 item
  264. Ribonucleotide Reductases 1 item
  265. HSP70 1 item
  266. Pregnane X receptor(PXR) 1 item
  267. ITK 1 item
  268. NUAK 1 item
  269. DCLK2 1 item
  270. FAAH 1 item
  271. PTK 1 item
  272. L3MBTL 1 item
  273. MDMX 1 item
  274. TYK2 1 item
  275. MUSK 1 item
  276. MAP3K 1 item
  277. AMPA Receptors 1 item
  278. Lck 2 items
  279. SERT 1 item
  280. DprE 1 item
  281. Vitamin D 1 item
  282. Flk1 2 items
  283. p21 1 item
  284. DHFR 1 item
  285. GARFT 1 item
  286. FGR 1 item
  287. YES 1 item
  288. Fyn 1 item
  289. ARG 1 item
  290. Autotaxin 1 item
  291. UCH 1 item
  292. RHA 1 item
  293. TRPC channel 1 item
  294. enoyl-acyl-carrier protein reductase 1 item
  295. FKBP 1 item
  296. Bcl-w 1 item
  297. topoisomerase 1 item
  298. PPK 1 item
  299. c-Syk 1 item
  300. CDK1/CyclinB 1 item
  301. IDO 1 item
  302. FXR 1 item
  303. reverse transcriptase 1 item
  304. Vascular Disrupting Agents (VDA) 1 item
  305. Androgen Receptor 1 item
  306. gp120/CD4 1 item
  307. ATM 2 items
  308. Sirtuin 1 item
  309. NE 1 item
  310. PIKfyve 1 item
  311. Glycogen Phosphorylases 1 item
  312. MTH1 1 item
  313. Insulin Receptor 1 item
  314. NS3/4a Proteases 1 item
  315. p90 S6K 1 item
Reported Experiments
  1. Animal Experiments 22 items
  2. Cell Experiments 18 items
Related Disease
  1. Breast Cancer 4 items
  2. Cancer 17 items
  3. Colorectal Cancer 1 item
  4. Glioblastoma 2 items
  5. Glioma 1 item
  6. Lung Cancer 2 items
  7. Ovarian Cancer 2 items
  8. Prostate Cancer 2 items
  9. Renal Cancer 1 item