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 Paper Citing APExBIO Products  Ongoing Clinical Trials  Solubility in DMSO  Solubility in Water  Solubility in Ethanol  Solubility in Dimethyl Formamide
  1. VS-5584 (SB2343)
    A3927 VS-5584 (SB2343)
    Target: PI3K|mTOR
    Summary: MTOR/P13K inhibitor,potent and selective
      ≥17.7 mg/mL
      ≥4.71 mg/mL
      <2.23 mg/mL
  2. Trametinib (GSK1120212)
    A3018 Trametinib (GSK1120212)
     7 Citation
    Target: MEK
    Summary: MEK1 and MEK2 inhibitor, potent and selective
      ≥15.38 mg/mL
  3. Panobinostat (LBH589)
    A8178 Panobinostat (LBH589)
     10 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      ≥17.47 mg/mL
      <3.19 mg/mL
      <2.27 mg/mL
  4. Ispinesib (SB-715992)
    A5343 Ispinesib (SB-715992)
    Target: Ksp
    Summary: Kinesin spindle protein (KSP)inhibitor
      ≥25.85 mg/mL
      ≥48.4 mg/mL
      <2.47 mg/mL
  5. C646
    B1577 C646
     1 Citation
    Target: p300
    Summary: HAT p300-CBP inhibitor,cell-permeable
      ≥11.1 mg/mL
  6. LDE225 (NVP-LDE225,Erismodegib)
    B2266 LDE225 (NVP-LDE225,Erismodegib)
     1 Citation
    Target: Smoothened
    Summary: Smoothened inhibitor,potent and selective
      ≥24.3 mg/mL
  7. OTSSP167
    B1321 OTSSP167
    Target: MELK
    Summary: MELK inhibitor
      <0.97 mg/mL
  8. Beta-Lapachone
    B2290 Beta-Lapachone
    Target: Topoisomerases
    Summary: DNA topoisomerase I inhibitor,selective
      ≥10.85 mg/mL
  9. TOK-001
    A8623 TOK-001
    Target: Androgen Receptors|Cytochrome P450 (CYP450)
    Summary: CYP17 inhibitor and androgen receptor (AR) antagonist
      ≥12.4 mg/mL
  10. CCT128930
    A8617 CCT128930
    Target: Akt
    Summary: AKT inhibitor
      ≥17.1 mg/mL

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