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Home >> Signaling Pathways >> Proteases >> HCV Protease

HCV Protease

Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.

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Biochemicals

  1. Cat.No. Product Name Information
  2. A8189 PSI-6206 Top Seller Inhibitor of HCV RNA polymerase,potent and selective
  3. A3737 PSI-6130 Inhibitor of HCV nucleoside polymerase,selective and effective
  4. A5618 Daclatasvir (BMS-790052) HCV NS5A inhibitor
  5. A3261 Boceprevir HCV protease inhibitor,potent and selective
  6. A8898 HZ-1157 HCV NS3/4A protease inhibitor
  7. A4032 VX-222 (VCH-222, Lomibuvir) NNI of HCV RNA polymerase
  8. A4031 Telaprevir (VX-950) HCV NS3-4A protease inhibitor
  9. A4024 Danoprevir (RG7227) HCV NS3/4A protease inhibitor
  10. A3217 Balapiravir Polymerase inhibitor,anti-HCV
  11. A3820 Simeprevir Inhibitor of HCV NS3/4A protease
  12. A3643 Narlaprevir HCV NS3 protease inhibitor
  13. A3864 Tegobuvir HCV RNA replication inhibitor
  14. A3257 BMS-790052 dihydrochloride HCV NS5A inhibitor
  15. A3182 Anguizole Inhibitor of HCV replication
  16. A3908 Vaniprevir Hepatitis C virus NS3/4a protease inhibitor
  17. A3772 RO-9187 HCV virus replication inhibitor
  18. A3195 Asunaprevir (BMS-650032) NS3 protease inhibitor
  19. A3655 Nesbuvir NS5B polymerase inhibitor